Localization and contents of paradisins, the most potent CYP3A4 inhibitors, in grapefruit Citrus paradisii and grapefruit juice

Tomihisa Ohta, Yasuyo Miyamoto, Takuro Maruyama, Fumiyuki Kiuchi, Sachiko Tsukamoto

Research output: Contribution to journalArticle

5 Citations (Scopus)


Paradisins A-C originally isolated from grapefruit juice are found to be the most potent CYP3A4 inhibitors discovered so far. The presence of the intact paradisins was confirmed in the unprocessed fruit Citrus paradisii. In commercially available grapefruit juice, paradisins localized only in the pale yellow solid (pulp) but not in pulp-free liquid. Although the contents of paradisins A and B in juice were almost the same as that in unprocessed fruit, the content of paradisin C in juice was one-tenth of that in unprocessed fruit because of its instability.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalNatural Medicines
Issue number6
Publication statusPublished - 2002 Dec 1
Externally publishedYes



  • CYP3A inhibition
  • Citrus paradisii
  • Furanocoumarin dimers
  • Grapefruit
  • Grapefruit juice
  • Localization
  • Paradisin
  • Rutaceae

ASJC Scopus subject areas

  • Molecular Medicine

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