Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

N. Takahashi, H. Tuiki, Hideyuki Saya, K. Kaibuchi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. To elucidate the role of ROCK II in human disease, we have cloned a 4363-bp cDNA encoding human ROCK II. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Radiation hybrid mapping has shown that the human ROCK II gene is located very close to the highly polymorphic marker D2S359.

Original languageEnglish
Pages (from-to)235-237
Number of pages3
JournalGenomics
Volume55
Issue number2
DOIs
Publication statusPublished - 1999 Jan 15
Externally publishedYes

Fingerprint

rho-Associated Kinases
Human Chromosomes
Genes
Serum Response Element
Radiation Hybrid Mapping
Stress Fibers
Focal Adhesions
Cytokinesis
Monomeric GTP-Binding Proteins
Protein-Serine-Threonine Kinases
Muscle Contraction
Fluorescence In Situ Hybridization
Isoenzymes
Smooth Muscle
Actins
Complementary DNA
Chromosomes
Amino Acids

ASJC Scopus subject areas

  • Genetics

Cite this

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. / Takahashi, N.; Tuiki, H.; Saya, Hideyuki; Kaibuchi, K.

In: Genomics, Vol. 55, No. 2, 15.01.1999, p. 235-237.

Research output: Contribution to journalArticle

Takahashi, N. ; Tuiki, H. ; Saya, Hideyuki ; Kaibuchi, K. / Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. In: Genomics. 1999 ; Vol. 55, No. 2. pp. 235-237.
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