Localized or diffuse lesions of the submandibular glands localized diffuse in immunoglobulin g4-related disease in association with differential organ involvement

Satomi Asai, Kenji Okami, Naoya Nakamura, Shuichi Shiraishi, Ryousuke Sugimoto, Damdinsuren Anar, Shinji Sato, Hiromichi Matsushita, Yasuo Suzuki, Hayato Miyachi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objectives-The purpose of this study was to assess the relationship between the sonographic characteristics of the submandibular glands and organ involvement at the initial presentation in patients with immunoglobulin G4 (IgG4)-related disease. Methods-We conducted a retrospective study that included 15 patients who had bilateral swollen submandibular glands and elevated serum IgG4 levels between January 2005 and December 2010. Results-In all 15 patients, sonography revealed the involvement of both sides of the submandibular glands. The sonographic appearance of each gland was classified into two types: localized tumor-forming and diffuse focal types. On the basis of this typing, all 15 patients were classified into two groups: a group with the localized tumor-forming type observed on one or both sides of the glands (n = 10) and a group with the diffuse focal type present on both sides (n = 5). All 10 patients in the former group had lesions in local exocrine organs, such as the lacrimal and parotid glands, with regional lymphadenopathy. In contrast, all 5 patients in the latter group had lesions in abdominal organs, such as autoimmune pancreatitis and sclerosing cholangitis. Conclusions-The sonographic patterns of the submandibular glands in patients with IgG4-related disease can be divided into two types: localized tumor-forming and diffuse focal. The distinctive patient groups defined by the sonographic patterns in both glands were associated with differential organ involvement and thus could be used as indicators of the disease extension and specific organ involvement.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalJournal of Ultrasound in Medicine
Volume32
Issue number5
DOIs
Publication statusPublished - 2013 May 1
Externally publishedYes

Keywords

  • Immunoglobulin G4-related disease
  • Organ involvement
  • Salivary glands
  • Sonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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