Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: Population based prospective cohort study

Akira Sekikawa, Katsuyuki Miura, Sunghee Lee, Akira Fujiyoshi, Daniel Edmundowicz, Takashi Kadowaki, Rhobert W. Evans, Sayaka Kadowaki, Kim Sutton-Tyrrell, Tomonori Okamura, Marnie Bertolet, Kamal H. Masaki, Yasuyuki Nakamura, Emma J M Barinas-Mitchell, Bradley J. Willcox, Aya Kadota, Todd B. Seto, Hiroshi Maegawa, Lewis H. Kuller, Hirotsugu Ueshima

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Abstract

Objective: To determine whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA. Methods: In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40.49 years at baseline (2002.2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007.2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS≥10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline. Results: Mean (SD) serum percentage of LCn3PUFA was >100% higher in Japanese men than in white men (9.08 (2.49) vs 3.84 (1.79), respectively, p<0.01). Japanese men had a significantly lower incidence rate of CAC compared to white men (0.9 vs 2.9/100 personyears, respectively, p<0.01). The incidence rate ratio of CAC taking follow-up time into account between Japanese and white men was 0.321 (95% CI 0.150 to 0.690; p<0.01). After adjusting for age, systolic blood pressure, low density lipoprotein cholesterol, diabetes, and other potential confounders, the ratio remained significant (0.262, 95% CI 0.094 to 0.731; p=0.01). After further adjusting for LCn3PUFAs, however, the ratio was attenuated and became non-significant (0.376, 95% CI 0.090 to 1.572; p=0.18). Conclusions: LCn3PUFAs significantly contributed to the difference in the incidence of CAC between Japanese and white men.

Original languageEnglish
Pages (from-to)569-573
Number of pages5
JournalHeart
Volume100
Issue number7
DOIs
Publication statusPublished - 2014

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Omega-3 Fatty Acids
Coronary Vessels
Japan
Cohort Studies
Prospective Studies
Incidence
Population
Serum
Blood Pressure
LDL Cholesterol
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA : Population based prospective cohort study. / Sekikawa, Akira; Miura, Katsuyuki; Lee, Sunghee; Fujiyoshi, Akira; Edmundowicz, Daniel; Kadowaki, Takashi; Evans, Rhobert W.; Kadowaki, Sayaka; Sutton-Tyrrell, Kim; Okamura, Tomonori; Bertolet, Marnie; Masaki, Kamal H.; Nakamura, Yasuyuki; Barinas-Mitchell, Emma J M; Willcox, Bradley J.; Kadota, Aya; Seto, Todd B.; Maegawa, Hiroshi; Kuller, Lewis H.; Ueshima, Hirotsugu.

In: Heart, Vol. 100, No. 7, 2014, p. 569-573.

Research output: Contribution to journalArticle

Sekikawa, A, Miura, K, Lee, S, Fujiyoshi, A, Edmundowicz, D, Kadowaki, T, Evans, RW, Kadowaki, S, Sutton-Tyrrell, K, Okamura, T, Bertolet, M, Masaki, KH, Nakamura, Y, Barinas-Mitchell, EJM, Willcox, BJ, Kadota, A, Seto, TB, Maegawa, H, Kuller, LH & Ueshima, H 2014, 'Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: Population based prospective cohort study', Heart, vol. 100, no. 7, pp. 569-573. https://doi.org/10.1136/heartjnl-2013-304421
Sekikawa, Akira ; Miura, Katsuyuki ; Lee, Sunghee ; Fujiyoshi, Akira ; Edmundowicz, Daniel ; Kadowaki, Takashi ; Evans, Rhobert W. ; Kadowaki, Sayaka ; Sutton-Tyrrell, Kim ; Okamura, Tomonori ; Bertolet, Marnie ; Masaki, Kamal H. ; Nakamura, Yasuyuki ; Barinas-Mitchell, Emma J M ; Willcox, Bradley J. ; Kadota, Aya ; Seto, Todd B. ; Maegawa, Hiroshi ; Kuller, Lewis H. ; Ueshima, Hirotsugu. / Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA : Population based prospective cohort study. In: Heart. 2014 ; Vol. 100, No. 7. pp. 569-573.
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abstract = "Objective: To determine whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA. Methods: In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40.49 years at baseline (2002.2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007.2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS≥10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline. Results: Mean (SD) serum percentage of LCn3PUFA was >100{\%} higher in Japanese men than in white men (9.08 (2.49) vs 3.84 (1.79), respectively, p<0.01). Japanese men had a significantly lower incidence rate of CAC compared to white men (0.9 vs 2.9/100 personyears, respectively, p<0.01). The incidence rate ratio of CAC taking follow-up time into account between Japanese and white men was 0.321 (95{\%} CI 0.150 to 0.690; p<0.01). After adjusting for age, systolic blood pressure, low density lipoprotein cholesterol, diabetes, and other potential confounders, the ratio remained significant (0.262, 95{\%} CI 0.094 to 0.731; p=0.01). After further adjusting for LCn3PUFAs, however, the ratio was attenuated and became non-significant (0.376, 95{\%} CI 0.090 to 1.572; p=0.18). Conclusions: LCn3PUFAs significantly contributed to the difference in the incidence of CAC between Japanese and white men.",
author = "Akira Sekikawa and Katsuyuki Miura and Sunghee Lee and Akira Fujiyoshi and Daniel Edmundowicz and Takashi Kadowaki and Evans, {Rhobert W.} and Sayaka Kadowaki and Kim Sutton-Tyrrell and Tomonori Okamura and Marnie Bertolet and Masaki, {Kamal H.} and Yasuyuki Nakamura and Barinas-Mitchell, {Emma J M} and Willcox, {Bradley J.} and Aya Kadota and Seto, {Todd B.} and Hiroshi Maegawa and Kuller, {Lewis H.} and Hirotsugu Ueshima",
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T1 - Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA

T2 - Population based prospective cohort study

AU - Sekikawa, Akira

AU - Miura, Katsuyuki

AU - Lee, Sunghee

AU - Fujiyoshi, Akira

AU - Edmundowicz, Daniel

AU - Kadowaki, Takashi

AU - Evans, Rhobert W.

AU - Kadowaki, Sayaka

AU - Sutton-Tyrrell, Kim

AU - Okamura, Tomonori

AU - Bertolet, Marnie

AU - Masaki, Kamal H.

AU - Nakamura, Yasuyuki

AU - Barinas-Mitchell, Emma J M

AU - Willcox, Bradley J.

AU - Kadota, Aya

AU - Seto, Todd B.

AU - Maegawa, Hiroshi

AU - Kuller, Lewis H.

AU - Ueshima, Hirotsugu

PY - 2014

Y1 - 2014

N2 - Objective: To determine whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA. Methods: In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40.49 years at baseline (2002.2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007.2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS≥10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline. Results: Mean (SD) serum percentage of LCn3PUFA was >100% higher in Japanese men than in white men (9.08 (2.49) vs 3.84 (1.79), respectively, p<0.01). Japanese men had a significantly lower incidence rate of CAC compared to white men (0.9 vs 2.9/100 personyears, respectively, p<0.01). The incidence rate ratio of CAC taking follow-up time into account between Japanese and white men was 0.321 (95% CI 0.150 to 0.690; p<0.01). After adjusting for age, systolic blood pressure, low density lipoprotein cholesterol, diabetes, and other potential confounders, the ratio remained significant (0.262, 95% CI 0.094 to 0.731; p=0.01). After further adjusting for LCn3PUFAs, however, the ratio was attenuated and became non-significant (0.376, 95% CI 0.090 to 1.572; p=0.18). Conclusions: LCn3PUFAs significantly contributed to the difference in the incidence of CAC between Japanese and white men.

AB - Objective: To determine whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA. Methods: In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40.49 years at baseline (2002.2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007.2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS≥10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline. Results: Mean (SD) serum percentage of LCn3PUFA was >100% higher in Japanese men than in white men (9.08 (2.49) vs 3.84 (1.79), respectively, p<0.01). Japanese men had a significantly lower incidence rate of CAC compared to white men (0.9 vs 2.9/100 personyears, respectively, p<0.01). The incidence rate ratio of CAC taking follow-up time into account between Japanese and white men was 0.321 (95% CI 0.150 to 0.690; p<0.01). After adjusting for age, systolic blood pressure, low density lipoprotein cholesterol, diabetes, and other potential confounders, the ratio remained significant (0.262, 95% CI 0.094 to 0.731; p=0.01). After further adjusting for LCn3PUFAs, however, the ratio was attenuated and became non-significant (0.376, 95% CI 0.090 to 1.572; p=0.18). Conclusions: LCn3PUFAs significantly contributed to the difference in the incidence of CAC between Japanese and white men.

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