Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese

A 24-year follow-up of NIPPON DATA80

Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Akira Sekikawa, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake. Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population. Methods: We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake. Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37%kcal (0.86g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P=0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline). Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalAtherosclerosis
Volume232
Issue number2
DOIs
Publication statusPublished - 2014 Feb

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Omega-3 Fatty Acids
Cardiovascular Diseases
Mortality
Confidence Intervals
Population
Proportional Hazards Models
Coronary Disease
Japan
Age Groups
Stroke
Myocardial Infarction
Food

Keywords

  • Cardiovascular disease mortality
  • Cohort study
  • Long-chain n-3 polyunsaturated fatty acid
  • Nutrition

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese : A 24-year follow-up of NIPPON DATA80. / Miyagawa, Naoko; Miura, Katsuyuki; Okuda, Nagako; Kadowaki, Takashi; Takashima, Naoyuki; Nagasawa, Shin ya; Nakamura, Yasuyuki; Matsumura, Yasuhiro; Hozawa, Atsushi; Fujiyoshi, Akira; Hisamatsu, Takashi; Yoshita, Katsushi; Sekikawa, Akira; Ohkubo, Takayoshi; Abbott, Robert D.; Okamura, Tomonori; Okayama, Akira; Ueshima, Hirotsugu.

In: Atherosclerosis, Vol. 232, No. 2, 02.2014, p. 384-389.

Research output: Contribution to journalArticle

Miyagawa, N, Miura, K, Okuda, N, Kadowaki, T, Takashima, N, Nagasawa, SY, Nakamura, Y, Matsumura, Y, Hozawa, A, Fujiyoshi, A, Hisamatsu, T, Yoshita, K, Sekikawa, A, Ohkubo, T, Abbott, RD, Okamura, T, Okayama, A & Ueshima, H 2014, 'Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80', Atherosclerosis, vol. 232, no. 2, pp. 384-389. https://doi.org/10.1016/j.atherosclerosis.2013.11.073
Miyagawa, Naoko ; Miura, Katsuyuki ; Okuda, Nagako ; Kadowaki, Takashi ; Takashima, Naoyuki ; Nagasawa, Shin ya ; Nakamura, Yasuyuki ; Matsumura, Yasuhiro ; Hozawa, Atsushi ; Fujiyoshi, Akira ; Hisamatsu, Takashi ; Yoshita, Katsushi ; Sekikawa, Akira ; Ohkubo, Takayoshi ; Abbott, Robert D. ; Okamura, Tomonori ; Okayama, Akira ; Ueshima, Hirotsugu. / Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese : A 24-year follow-up of NIPPON DATA80. In: Atherosclerosis. 2014 ; Vol. 232, No. 2. pp. 384-389.
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abstract = "Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake. Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population. Methods: We followed-up a total of 9190 individuals (56.2{\%} women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake. Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37{\%}kcal (0.86g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95{\%} CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P=0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline). Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake.",
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T1 - Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese

T2 - A 24-year follow-up of NIPPON DATA80

AU - Miyagawa, Naoko

AU - Miura, Katsuyuki

AU - Okuda, Nagako

AU - Kadowaki, Takashi

AU - Takashima, Naoyuki

AU - Nagasawa, Shin ya

AU - Nakamura, Yasuyuki

AU - Matsumura, Yasuhiro

AU - Hozawa, Atsushi

AU - Fujiyoshi, Akira

AU - Hisamatsu, Takashi

AU - Yoshita, Katsushi

AU - Sekikawa, Akira

AU - Ohkubo, Takayoshi

AU - Abbott, Robert D.

AU - Okamura, Tomonori

AU - Okayama, Akira

AU - Ueshima, Hirotsugu

PY - 2014/2

Y1 - 2014/2

N2 - Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake. Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population. Methods: We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake. Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37%kcal (0.86g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P=0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline). Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake.

AB - Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake. Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population. Methods: We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake. Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37%kcal (0.86g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P=0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline). Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake.

KW - Cardiovascular disease mortality

KW - Cohort study

KW - Long-chain n-3 polyunsaturated fatty acid

KW - Nutrition

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