Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss

Yasushi Ino, Magdalena C. Zlatescu, Hikaru Sasaki, David R. Macdonald, Anat O. Stemmer-Rachamimov, Sarah Jhung, David A. Ramsay, Andreas Von Deimling, David N. Louis, J. Gregory Cairncross

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Object. Allelic loss of chromosome 1p is a powerful predictor of tumor chemosensitivity and prolonged survival in patients with anaplastic oligodendrogliomas. Chromosome 1p loss also occurs in astrocytic and oligoastrocytic gliomas, although less commonly than in pure oligodendroglial tumors. This observation raises the possibility investigated in this study that chromosome 1p loss might also provide prognostic information for patients with high-grade gliomas with astrocytic components. Methods. The authors report on seven patients with high-grade-gliomas composed of either pure astrocytic or mixed astrocytic-oligodendroglial phenotypes, who had remarkable neuroradiological responses to therapy or unexpectedly long survivals. All of the tumors from these seven patients demonstrated chromosome 1p loss, whereas other genetic alterations characteristic of high- grade gliomas (p53 gene mutations, EGFR gene amplification, chromosome 10 loss, chromosome 19q loss, or CDKN2A/p16 deletions) were only found in occasional cases. The authors also assessed the frequency of chromosome 1p loss in a series of anonymous high-grade astrocytoma samples obtained from a tumor bank and demonstrate that this genetic change is uncommon, occurring in only 10% of cases. Conclusions. Although any prognostic importance of chromosome 1p loss in astrocytic or mixed astrocytic-oligodendroglial gliomas can only be determined in larger and prospective series, these findings raise the possibility that some high-grade gliomas with chromosome 1p loss, in addition to pure anaplastic oligodendrogliomas, may follow a more favorable clinical course.

Original languageEnglish
Pages (from-to)983-990
Number of pages8
JournalJournal of Neurosurgery
Volume92
Issue number6
DOIs
Publication statusPublished - 2000 Jan 1
Externally publishedYes

Fingerprint

Glioma
Chromosomes
Survival
Astrocytoma
Oligodendroglioma
Therapeutics
Neoplasms
erbB-1 Genes
Chromosomes, Human, Pair 10
Gene Amplification
Loss of Heterozygosity
p53 Genes
Phenotype
Mutation

Keywords

  • Chromosome marker
  • Glioblastoma multiforme
  • Oligodendroglioma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss. / Ino, Yasushi; Zlatescu, Magdalena C.; Sasaki, Hikaru; Macdonald, David R.; Stemmer-Rachamimov, Anat O.; Jhung, Sarah; Ramsay, David A.; Von Deimling, Andreas; Louis, David N.; Cairncross, J. Gregory.

In: Journal of Neurosurgery, Vol. 92, No. 6, 01.01.2000, p. 983-990.

Research output: Contribution to journalArticle

Ino, Y, Zlatescu, MC, Sasaki, H, Macdonald, DR, Stemmer-Rachamimov, AO, Jhung, S, Ramsay, DA, Von Deimling, A, Louis, DN & Cairncross, JG 2000, 'Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss', Journal of Neurosurgery, vol. 92, no. 6, pp. 983-990. https://doi.org/10.3171/jns.2000.92.6.0983
Ino, Yasushi ; Zlatescu, Magdalena C. ; Sasaki, Hikaru ; Macdonald, David R. ; Stemmer-Rachamimov, Anat O. ; Jhung, Sarah ; Ramsay, David A. ; Von Deimling, Andreas ; Louis, David N. ; Cairncross, J. Gregory. / Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss. In: Journal of Neurosurgery. 2000 ; Vol. 92, No. 6. pp. 983-990.
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abstract = "Object. Allelic loss of chromosome 1p is a powerful predictor of tumor chemosensitivity and prolonged survival in patients with anaplastic oligodendrogliomas. Chromosome 1p loss also occurs in astrocytic and oligoastrocytic gliomas, although less commonly than in pure oligodendroglial tumors. This observation raises the possibility investigated in this study that chromosome 1p loss might also provide prognostic information for patients with high-grade gliomas with astrocytic components. Methods. The authors report on seven patients with high-grade-gliomas composed of either pure astrocytic or mixed astrocytic-oligodendroglial phenotypes, who had remarkable neuroradiological responses to therapy or unexpectedly long survivals. All of the tumors from these seven patients demonstrated chromosome 1p loss, whereas other genetic alterations characteristic of high- grade gliomas (p53 gene mutations, EGFR gene amplification, chromosome 10 loss, chromosome 19q loss, or CDKN2A/p16 deletions) were only found in occasional cases. The authors also assessed the frequency of chromosome 1p loss in a series of anonymous high-grade astrocytoma samples obtained from a tumor bank and demonstrate that this genetic change is uncommon, occurring in only 10{\%} of cases. Conclusions. Although any prognostic importance of chromosome 1p loss in astrocytic or mixed astrocytic-oligodendroglial gliomas can only be determined in larger and prospective series, these findings raise the possibility that some high-grade gliomas with chromosome 1p loss, in addition to pure anaplastic oligodendrogliomas, may follow a more favorable clinical course.",
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AU - Ino, Yasushi

AU - Zlatescu, Magdalena C.

AU - Sasaki, Hikaru

AU - Macdonald, David R.

AU - Stemmer-Rachamimov, Anat O.

AU - Jhung, Sarah

AU - Ramsay, David A.

AU - Von Deimling, Andreas

AU - Louis, David N.

AU - Cairncross, J. Gregory

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N2 - Object. Allelic loss of chromosome 1p is a powerful predictor of tumor chemosensitivity and prolonged survival in patients with anaplastic oligodendrogliomas. Chromosome 1p loss also occurs in astrocytic and oligoastrocytic gliomas, although less commonly than in pure oligodendroglial tumors. This observation raises the possibility investigated in this study that chromosome 1p loss might also provide prognostic information for patients with high-grade gliomas with astrocytic components. Methods. The authors report on seven patients with high-grade-gliomas composed of either pure astrocytic or mixed astrocytic-oligodendroglial phenotypes, who had remarkable neuroradiological responses to therapy or unexpectedly long survivals. All of the tumors from these seven patients demonstrated chromosome 1p loss, whereas other genetic alterations characteristic of high- grade gliomas (p53 gene mutations, EGFR gene amplification, chromosome 10 loss, chromosome 19q loss, or CDKN2A/p16 deletions) were only found in occasional cases. The authors also assessed the frequency of chromosome 1p loss in a series of anonymous high-grade astrocytoma samples obtained from a tumor bank and demonstrate that this genetic change is uncommon, occurring in only 10% of cases. Conclusions. Although any prognostic importance of chromosome 1p loss in astrocytic or mixed astrocytic-oligodendroglial gliomas can only be determined in larger and prospective series, these findings raise the possibility that some high-grade gliomas with chromosome 1p loss, in addition to pure anaplastic oligodendrogliomas, may follow a more favorable clinical course.

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