Long-term depression at parallel fiber-Purkinje cell synapses

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Long-term depression (LTD) at parallel fi ber (PF) -Purkinje cell (PC) synapses is thought to play an important role in cerebellar motor learning. LTD is mediated by postsynaptic AMPA receptor endocytosis. Concurrent activation of PF and climbing fi bers generates specifi c temporal and spatial Ca 2+ dynamics in PC dendritic spines leading to activation of signaling cascade required for LTD.

Original languageEnglish
Title of host publicationEssentials of Cerebellum and Cerebellar Disorders
Subtitle of host publicationA Primer for Graduate Students
PublisherSpringer International Publishing
Pages329-334
Number of pages6
ISBN (Electronic)9783319245515
ISBN (Print)9783319245492
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Albus
  • Climbing fi ber
  • Long-term depression
  • LTD
  • Marr
  • Motor learning
  • Nitric oxide
  • Parallel fi ber

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

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  • Cite this

    Kohda, K., Kakegawa, W., & Yuzaki, M. (2016). Long-term depression at parallel fiber-Purkinje cell synapses. In Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students (pp. 329-334). Springer International Publishing. https://doi.org/10.1007/978-3-319-24551-5_45