Long-term depression at parallel fiber-Purkinje cell synapses

Kazuhisa Kouda; Wataru Kakegawa; Michisuke Yuzaki

doi:10.1007/978-3-319-24551-5_45

Long-term depression at parallel fiber-Purkinje cell synapses

Kazuhisa Kouda, Wataru Kakegawa, Michisuke Yuzaki

Department of Physiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Long-term depression (LTD) at parallel fi ber (PF) -Purkinje cell (PC) synapses is thought to play an important role in cerebellar motor learning. LTD is mediated by postsynaptic AMPA receptor endocytosis. Concurrent activation of PF and climbing fi bers generates specifi c temporal and spatial Ca 2+ dynamics in PC dendritic spines leading to activation of signaling cascade required for LTD.

Original language	English
Title of host publication	Essentials of Cerebellum and Cerebellar Disorders
Subtitle of host publication	A Primer for Graduate Students
Publisher	Springer International Publishing
Pages	329-334
Number of pages	6
ISBN (Electronic)	9783319245515
ISBN (Print)	9783319245492
DOIs	https://doi.org/10.1007/978-3-319-24551-5_45
Publication status	Published - 2016 Jan 1

Keywords

Albus
Climbing fi ber
Long-term depression
LTD
Marr
Motor learning
Nitric oxide
Parallel fi ber

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Neuroscience(all)
Agricultural and Biological Sciences(all)

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10.1007/978-3-319-24551-5_45

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KW - Nitric oxide

KW - Parallel fi ber

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Long-term depression at parallel fiber-Purkinje cell synapses

Abstract

Keywords

ASJC Scopus subject areas

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