Long-Term Effects of Intensive Blood Pressure Lowering on Arterial Wall Stiffness in Hypertensive Patients

Atsuhiro Ichihara, Matsuhiko Hayashi, Yukako Koura, Yuko Tada, Nobuhisa Hirota, Takao Saruta

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Aortic stiffness is assessed by pulse wave velocity (PWV) and predicts the cardiovascular morbidity and mortality of hypertensive patients. To determine the long-term effects of intensive blood pressure (BP) lowering by antihypertensive drug therapy on aortic stiffness assessed by PWV, a single-blind randomized prospective study was performed. Methods: One hundred forty nondiabetic hypertensive patients (67.6 ± 0.9 years old; systolic/diastolic BP: 177 ± 1/101 ± 1 mm Hg) were assigned to an intensive control group (IC) with a target BP of <130/85 mm Hg (n = 71) or a moderate control group (MC) with a target BP of <140/90 mm Hg (n = 69), and aortic stiffness was assessed every 3 months by measuring aortic PWV with a pulse pressure analyzer. Results: During the 12-month treatment period, BP significantly decreased to 129 ± 1/78 ± 1 mm Hg and 152 ± 2/87 ± 1 mm Hg in the IC and MC, respectively. At the beginning of the study, PWV in the IC and MC was similar, averaging 1779 ± 41 and 1885 ± 50 cm/sec, respectively. By the end of the treatment period, however, PWV had decreased to 1621 ± 34 cm/sec in the IC, but had not changed significantly in the MC. In the IC, the ratio of the change in PWV to the change in BP increased with the duration of BP lowering. Clinical and biological parameters were similar in both groups, except that higher doses of amlodipine were used in the IC. Conclusions: Long-term intensive BP lowering in the hypertensive patients was associated with a significant reduction in aortic stiffness distinct from its acute depressor effect.

Original languageEnglish
Pages (from-to)959-965
Number of pages7
JournalAmerican Journal of Hypertension
Volume16
Issue number11 I
DOIs
Publication statusPublished - 2003 Nov

Fingerprint

Vascular Stiffness
Pulse Wave Analysis
Blood Pressure
Control Groups
Amlodipine
Antihypertensive Agents
Prospective Studies
Morbidity
Drug Therapy

Keywords

  • Antihypertensive therapy
  • Atherosclerosis
  • Blood pressure
  • Hypertension
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-Term Effects of Intensive Blood Pressure Lowering on Arterial Wall Stiffness in Hypertensive Patients. / Ichihara, Atsuhiro; Hayashi, Matsuhiko; Koura, Yukako; Tada, Yuko; Hirota, Nobuhisa; Saruta, Takao.

In: American Journal of Hypertension, Vol. 16, No. 11 I, 11.2003, p. 959-965.

Research output: Contribution to journalArticle

Ichihara, Atsuhiro ; Hayashi, Matsuhiko ; Koura, Yukako ; Tada, Yuko ; Hirota, Nobuhisa ; Saruta, Takao. / Long-Term Effects of Intensive Blood Pressure Lowering on Arterial Wall Stiffness in Hypertensive Patients. In: American Journal of Hypertension. 2003 ; Vol. 16, No. 11 I. pp. 959-965.
@article{72bb0ead3dd6449dab1bae6cc6c7b2be,
title = "Long-Term Effects of Intensive Blood Pressure Lowering on Arterial Wall Stiffness in Hypertensive Patients",
abstract = "Background: Aortic stiffness is assessed by pulse wave velocity (PWV) and predicts the cardiovascular morbidity and mortality of hypertensive patients. To determine the long-term effects of intensive blood pressure (BP) lowering by antihypertensive drug therapy on aortic stiffness assessed by PWV, a single-blind randomized prospective study was performed. Methods: One hundred forty nondiabetic hypertensive patients (67.6 ± 0.9 years old; systolic/diastolic BP: 177 ± 1/101 ± 1 mm Hg) were assigned to an intensive control group (IC) with a target BP of <130/85 mm Hg (n = 71) or a moderate control group (MC) with a target BP of <140/90 mm Hg (n = 69), and aortic stiffness was assessed every 3 months by measuring aortic PWV with a pulse pressure analyzer. Results: During the 12-month treatment period, BP significantly decreased to 129 ± 1/78 ± 1 mm Hg and 152 ± 2/87 ± 1 mm Hg in the IC and MC, respectively. At the beginning of the study, PWV in the IC and MC was similar, averaging 1779 ± 41 and 1885 ± 50 cm/sec, respectively. By the end of the treatment period, however, PWV had decreased to 1621 ± 34 cm/sec in the IC, but had not changed significantly in the MC. In the IC, the ratio of the change in PWV to the change in BP increased with the duration of BP lowering. Clinical and biological parameters were similar in both groups, except that higher doses of amlodipine were used in the IC. Conclusions: Long-term intensive BP lowering in the hypertensive patients was associated with a significant reduction in aortic stiffness distinct from its acute depressor effect.",
keywords = "Antihypertensive therapy, Atherosclerosis, Blood pressure, Hypertension, Pulse wave velocity",
author = "Atsuhiro Ichihara and Matsuhiko Hayashi and Yukako Koura and Yuko Tada and Nobuhisa Hirota and Takao Saruta",
year = "2003",
month = "11",
doi = "10.1016/S0895-7061(03)01004-5",
language = "English",
volume = "16",
pages = "959--965",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "11 I",

}

TY - JOUR

T1 - Long-Term Effects of Intensive Blood Pressure Lowering on Arterial Wall Stiffness in Hypertensive Patients

AU - Ichihara, Atsuhiro

AU - Hayashi, Matsuhiko

AU - Koura, Yukako

AU - Tada, Yuko

AU - Hirota, Nobuhisa

AU - Saruta, Takao

PY - 2003/11

Y1 - 2003/11

N2 - Background: Aortic stiffness is assessed by pulse wave velocity (PWV) and predicts the cardiovascular morbidity and mortality of hypertensive patients. To determine the long-term effects of intensive blood pressure (BP) lowering by antihypertensive drug therapy on aortic stiffness assessed by PWV, a single-blind randomized prospective study was performed. Methods: One hundred forty nondiabetic hypertensive patients (67.6 ± 0.9 years old; systolic/diastolic BP: 177 ± 1/101 ± 1 mm Hg) were assigned to an intensive control group (IC) with a target BP of <130/85 mm Hg (n = 71) or a moderate control group (MC) with a target BP of <140/90 mm Hg (n = 69), and aortic stiffness was assessed every 3 months by measuring aortic PWV with a pulse pressure analyzer. Results: During the 12-month treatment period, BP significantly decreased to 129 ± 1/78 ± 1 mm Hg and 152 ± 2/87 ± 1 mm Hg in the IC and MC, respectively. At the beginning of the study, PWV in the IC and MC was similar, averaging 1779 ± 41 and 1885 ± 50 cm/sec, respectively. By the end of the treatment period, however, PWV had decreased to 1621 ± 34 cm/sec in the IC, but had not changed significantly in the MC. In the IC, the ratio of the change in PWV to the change in BP increased with the duration of BP lowering. Clinical and biological parameters were similar in both groups, except that higher doses of amlodipine were used in the IC. Conclusions: Long-term intensive BP lowering in the hypertensive patients was associated with a significant reduction in aortic stiffness distinct from its acute depressor effect.

AB - Background: Aortic stiffness is assessed by pulse wave velocity (PWV) and predicts the cardiovascular morbidity and mortality of hypertensive patients. To determine the long-term effects of intensive blood pressure (BP) lowering by antihypertensive drug therapy on aortic stiffness assessed by PWV, a single-blind randomized prospective study was performed. Methods: One hundred forty nondiabetic hypertensive patients (67.6 ± 0.9 years old; systolic/diastolic BP: 177 ± 1/101 ± 1 mm Hg) were assigned to an intensive control group (IC) with a target BP of <130/85 mm Hg (n = 71) or a moderate control group (MC) with a target BP of <140/90 mm Hg (n = 69), and aortic stiffness was assessed every 3 months by measuring aortic PWV with a pulse pressure analyzer. Results: During the 12-month treatment period, BP significantly decreased to 129 ± 1/78 ± 1 mm Hg and 152 ± 2/87 ± 1 mm Hg in the IC and MC, respectively. At the beginning of the study, PWV in the IC and MC was similar, averaging 1779 ± 41 and 1885 ± 50 cm/sec, respectively. By the end of the treatment period, however, PWV had decreased to 1621 ± 34 cm/sec in the IC, but had not changed significantly in the MC. In the IC, the ratio of the change in PWV to the change in BP increased with the duration of BP lowering. Clinical and biological parameters were similar in both groups, except that higher doses of amlodipine were used in the IC. Conclusions: Long-term intensive BP lowering in the hypertensive patients was associated with a significant reduction in aortic stiffness distinct from its acute depressor effect.

KW - Antihypertensive therapy

KW - Atherosclerosis

KW - Blood pressure

KW - Hypertension

KW - Pulse wave velocity

UR - http://www.scopus.com/inward/record.url?scp=0142169503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142169503&partnerID=8YFLogxK

U2 - 10.1016/S0895-7061(03)01004-5

DO - 10.1016/S0895-7061(03)01004-5

M3 - Article

VL - 16

SP - 959

EP - 965

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 11 I

ER -