Long-term efficacy and predictive correlates of response to nivolumab in Japanese patients with esophageal cancer

Ken Kato, Yuichiro Doki, Takashi Ura, Yasuo Hamamoto, Takashi Kojima, Takahiro Tsushima, Shuichi Hironaka, Hiroki Hara, Toshihiro Kudo, Satoru Iwasa, Kei Muro, Hirofumi Yasui, Keiko Minashi, Kensei Yamaguchi, Atsushi Ohtsu, Yuko Kitagawa

Research output: Contribution to journalArticle

Abstract

The long-term efficacy of nivolumab in esophageal squamous cell carcinoma and its association with disease biomarkers are currently not well known. Therefore, we investigated the association in Japanese patients with treatment-refractory advanced esophageal cancer who participated in an open-label, single-arm, multicenter phase II study. Patients received nivolumab 3 mg/kg i.v. every 2 weeks until disease progression or unacceptable toxicity, and were followed up for 2 years after the initial dosing of the last patient. Archival tissue samples were collected before treatment and analyzed for programmed death ligand-1 (PD-L1) and CD8+ status of tumors and tumor-infiltrating lymphocytes (TILs) and human leukocyte antigen class 1. Efficacy end-points included objective response rate (ORR), overall survival (OS), progression-free survival (PFS), time to response, and duration of response. Of 65 enrolled patients (83% male), 64 were evaluable for efficacy and 41 (63%) for biomarkers. The ORR, median OS, and survival rate were 17.2%, 10.78 months, and 17.2%, respectively. Time to response was 1.45 months and duration of response was 11.17 months. The PD-L1 positivity of tumor cells was possibly associated with better PFS (2.04 vs 1.41 months, cut-off 1%) and OS (11.33 vs 6.24 months, cut-off 1%). Median OS was prolonged in patients with a median number of TILs greater than 63.75% vs 63.75% or less (11.33 vs 7.85 months). Nivolumab showed continued long-term efficacy, as seen by the stability of PFS and OS, in Japanese patients with esophageal squamous cell carcinoma. Further investigation of PD-L1 tumor expression and TILs as potential biomarkers for predicting patients likely to benefit from nivolumab therapy is warranted.

Original languageEnglish
Pages (from-to)1676-1684
Number of pages9
JournalCancer science
Volume111
Issue number5
DOIs
Publication statusPublished - 2020 May 1

Keywords

  • CD8 tumor-infiltrating lymphocyte
  • esophageal squamous cell carcinoma
  • long-term survival
  • nivolumab
  • programmed death-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Kato, K., Doki, Y., Ura, T., Hamamoto, Y., Kojima, T., Tsushima, T., Hironaka, S., Hara, H., Kudo, T., Iwasa, S., Muro, K., Yasui, H., Minashi, K., Yamaguchi, K., Ohtsu, A., & Kitagawa, Y. (2020). Long-term efficacy and predictive correlates of response to nivolumab in Japanese patients with esophageal cancer. Cancer science, 111(5), 1676-1684. https://doi.org/10.1111/cas.14380