Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Masaki Kimura, Naoto Tateishi, Tomoei Shiota, Fumihiko Yoshie, Hideki Yamauchi, Masato Suzuki, Toshiaki Shibasaki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalNeuroReport
Volume15
Issue number4
DOIs
Publication statusPublished - 2004 Mar 22

Fingerprint

AIDS-Related Complex
Leptin Receptors
Arcuate Nucleus of Hypothalamus
Down-Regulation
Leptin
Messenger RNA
Serum
Abdominal Fat
Insulin Resistance
Adipose Tissue
Wistar Rats
Insulin
Weights and Measures

Keywords

  • ARC
  • Arcuate nucleus of hypothalamus
  • Chronic
  • Exercise
  • Leptin receptor
  • Long-term
  • mRNA
  • Ob-Rb
  • Voluntary

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kimura, M., Tateishi, N., Shiota, T., Yoshie, F., Yamauchi, H., Suzuki, M., & Shibasaki, T. (2004). Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus. NeuroReport, 15(4), 713-716. https://doi.org/10.1097/00001756-200403220-00028

Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus. / Kimura, Masaki; Tateishi, Naoto; Shiota, Tomoei; Yoshie, Fumihiko; Yamauchi, Hideki; Suzuki, Masato; Shibasaki, Toshiaki.

In: NeuroReport, Vol. 15, No. 4, 22.03.2004, p. 713-716.

Research output: Contribution to journalArticle

Kimura, M, Tateishi, N, Shiota, T, Yoshie, F, Yamauchi, H, Suzuki, M & Shibasaki, T 2004, 'Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus', NeuroReport, vol. 15, no. 4, pp. 713-716. https://doi.org/10.1097/00001756-200403220-00028
Kimura, Masaki ; Tateishi, Naoto ; Shiota, Tomoei ; Yoshie, Fumihiko ; Yamauchi, Hideki ; Suzuki, Masato ; Shibasaki, Toshiaki. / Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus. In: NeuroReport. 2004 ; Vol. 15, No. 4. pp. 713-716.
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