Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Masaki Kimura, Naoto Tateishi, Tomoei Shiota, Fumihiko Yoshie, Hideki Yamauchi, Masato Suzuki, Toshiaki Shibasaki

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20 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalNeuroReport
Volume15
Issue number4
DOIs
Publication statusPublished - 2004 Mar 22

Keywords

  • ARC
  • Arcuate nucleus of hypothalamus
  • Chronic
  • Exercise
  • Leptin receptor
  • Long-term
  • Ob-Rb
  • Voluntary
  • mRNA

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kimura, M., Tateishi, N., Shiota, T., Yoshie, F., Yamauchi, H., Suzuki, M., & Shibasaki, T. (2004). Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus. NeuroReport, 15(4), 713-716. https://doi.org/10.1097/00001756-200403220-00028