Long-term implantation of primary islet cell-encapsulating hydrogel microfibers in diabetic mice

Hiroaki Onoe, Teru Okitsu, Akane Itou, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This paper describes long-term implantation of primary pancreatic islet cell fibers into diabetic mice. Primary rat pancreatic islet cells were encapsulated in core-shell hydrogel microfibers and implanted into renal capsular space of diabetic mice by using a microcatheter. The blood glucose concentration of the recipient mice were normalized for more than 36 days. This result shows that our cell fiber approach can be applied to long-term implantation and can provide primary islet cells with sufficient microenvironment to promote cellular functions in vivo.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1836-1838
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume3

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

    Fingerprint

Keywords

  • Cell encapsulation
  • Diabetes mellitus
  • Hydrogel
  • Implantation
  • Microfiber

ASJC Scopus subject areas

  • Bioengineering

Cite this

Onoe, H., Okitsu, T., Itou, A., & Takeuchi, S. (2013). Long-term implantation of primary islet cell-encapsulating hydrogel microfibers in diabetic mice. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 1836-1838). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 3). Chemical and Biological Microsystems Society.