Long-Term in vivo Experiment Protocol Using SD Rats

T. Ito, Y. Koya, N. Miki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Our group has been developing implantable artificial dialysis system to decrease burden of chronic kidney disease patients. To evaluate the device, long-Term in vivo experiments are mandatory. However, we need to complete the detailed design of the devices prior to the long-Term tests, which range from the temporal change of the device performance to time to surgical procedures. To do so, we need to conduct mid-and long-Term in vivo experiments for multiple times to acquire sufficient information. It is useful to use small animals, such as rats, for in vivo experiment. However, there is no prior work that discusses mid-and long-Term coagulation ability control in small animals. In this study, we investigated the heparin administration to manage the coagulability. A simplified device was connected to SD rats under coagulability control and the blood coagulation in the device was characterized. And succeeded in blood clotting inhibition for 48 hours

Original languageEnglish
Title of host publication2019 International Conference on Electronics Packaging, ICEP 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages144-148
Number of pages5
ISBN (Electronic)9784990218867
DOIs
Publication statusPublished - 2019 Apr
Event2019 International Conference on Electronics Packaging, ICEP 2019 - Niigata, Japan
Duration: 2019 Apr 172019 Apr 20

Publication series

Name2019 International Conference on Electronics Packaging, ICEP 2019

Conference

Conference2019 International Conference on Electronics Packaging, ICEP 2019
CountryJapan
CityNiigata
Period19/4/1719/4/20

Keywords

  • Implant
  • coagulation
  • dialysis
  • heparin
  • in vivo

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Metals and Alloys

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  • Cite this

    Ito, T., Koya, Y., & Miki, N. (2019). Long-Term in vivo Experiment Protocol Using SD Rats. In 2019 International Conference on Electronics Packaging, ICEP 2019 (pp. 144-148). [8733485] (2019 International Conference on Electronics Packaging, ICEP 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.23919/ICEP.2019.8733485