Long-term outcome in Japanese patients with lupus nephritis

M. Kono, S. Yasuda, M. Kato, Y. Kanetsuka, T. Kurita, Y. Fujieda, Kotaro Otomo, T. Horita, K. Oba, M. Kondo, M. Mukai, M. Yanai, Y. Fukasawa, T. Atsumi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according to the International Society of Nephrology and Renal Pathology Society classification. This retrospective analysis comprised 186 Japanese patients given a diagnosis of LN by renal specimen with a mean observation period of 12 years. Primary end point was defined as death or end-stage renal disease, and standardized mortality ratios were calculated. Five patients presented with histopathological class I, 62 with II, 21 with III or IIIV, 73 with IV or IVV and 25 with V. Fourteen deaths occurred, corresponding to an overall standardized mortality ratio of 3.59 (95% confidence interval 2.02-5.81, p<0.0001). Kaplan-Meier analysis revealed a 10-year overall survival of 95.7%. Nephrotic proteinuria (≥3.5 g/day) at baseline was identified as an independent poor prognostic factor for overall survival in Cox regression analysis. Kaplan-Meier analysis revealed a 10-year renal survival as 94.3%. Male gender and nephrotic proteinuria at baseline were identified as independent poor prognostic factors for renal survival in Cox regression analysis. In conclusion, LN was associated with a 3.59-fold increase in mortality compared with the general population. Male gender and nephrotic proteinuria were predictive for poor renal outcome.

Original languageEnglish
Pages (from-to)1124-1132
Number of pages9
JournalLupus
Volume23
Issue number11
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Lupus Nephritis
Kidney
Proteinuria
Kaplan-Meier Estimate
Mortality
Regression Analysis
Survival
Chronic Kidney Failure
Observation
Confidence Intervals
Pathology
Population

Keywords

  • Nephritis
  • Renal lupus
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Kono, M., Yasuda, S., Kato, M., Kanetsuka, Y., Kurita, T., Fujieda, Y., ... Atsumi, T. (2014). Long-term outcome in Japanese patients with lupus nephritis. Lupus, 23(11), 1124-1132. https://doi.org/10.1177/0961203314536246

Long-term outcome in Japanese patients with lupus nephritis. / Kono, M.; Yasuda, S.; Kato, M.; Kanetsuka, Y.; Kurita, T.; Fujieda, Y.; Otomo, Kotaro; Horita, T.; Oba, K.; Kondo, M.; Mukai, M.; Yanai, M.; Fukasawa, Y.; Atsumi, T.

In: Lupus, Vol. 23, No. 11, 01.01.2014, p. 1124-1132.

Research output: Contribution to journalArticle

Kono, M, Yasuda, S, Kato, M, Kanetsuka, Y, Kurita, T, Fujieda, Y, Otomo, K, Horita, T, Oba, K, Kondo, M, Mukai, M, Yanai, M, Fukasawa, Y & Atsumi, T 2014, 'Long-term outcome in Japanese patients with lupus nephritis', Lupus, vol. 23, no. 11, pp. 1124-1132. https://doi.org/10.1177/0961203314536246
Kono M, Yasuda S, Kato M, Kanetsuka Y, Kurita T, Fujieda Y et al. Long-term outcome in Japanese patients with lupus nephritis. Lupus. 2014 Jan 1;23(11):1124-1132. https://doi.org/10.1177/0961203314536246
Kono, M. ; Yasuda, S. ; Kato, M. ; Kanetsuka, Y. ; Kurita, T. ; Fujieda, Y. ; Otomo, Kotaro ; Horita, T. ; Oba, K. ; Kondo, M. ; Mukai, M. ; Yanai, M. ; Fukasawa, Y. ; Atsumi, T. / Long-term outcome in Japanese patients with lupus nephritis. In: Lupus. 2014 ; Vol. 23, No. 11. pp. 1124-1132.
@article{8b8d29bab83945929815268bc41cd222,
title = "Long-term outcome in Japanese patients with lupus nephritis",
abstract = "The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according to the International Society of Nephrology and Renal Pathology Society classification. This retrospective analysis comprised 186 Japanese patients given a diagnosis of LN by renal specimen with a mean observation period of 12 years. Primary end point was defined as death or end-stage renal disease, and standardized mortality ratios were calculated. Five patients presented with histopathological class I, 62 with II, 21 with III or IIIV, 73 with IV or IVV and 25 with V. Fourteen deaths occurred, corresponding to an overall standardized mortality ratio of 3.59 (95{\%} confidence interval 2.02-5.81, p<0.0001). Kaplan-Meier analysis revealed a 10-year overall survival of 95.7{\%}. Nephrotic proteinuria (≥3.5 g/day) at baseline was identified as an independent poor prognostic factor for overall survival in Cox regression analysis. Kaplan-Meier analysis revealed a 10-year renal survival as 94.3{\%}. Male gender and nephrotic proteinuria at baseline were identified as independent poor prognostic factors for renal survival in Cox regression analysis. In conclusion, LN was associated with a 3.59-fold increase in mortality compared with the general population. Male gender and nephrotic proteinuria were predictive for poor renal outcome.",
keywords = "Nephritis, Renal lupus, Systemic lupus erythematosus",
author = "M. Kono and S. Yasuda and M. Kato and Y. Kanetsuka and T. Kurita and Y. Fujieda and Kotaro Otomo and T. Horita and K. Oba and M. Kondo and M. Mukai and M. Yanai and Y. Fukasawa and T. Atsumi",
year = "2014",
month = "1",
day = "1",
doi = "10.1177/0961203314536246",
language = "English",
volume = "23",
pages = "1124--1132",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "11",

}

TY - JOUR

T1 - Long-term outcome in Japanese patients with lupus nephritis

AU - Kono, M.

AU - Yasuda, S.

AU - Kato, M.

AU - Kanetsuka, Y.

AU - Kurita, T.

AU - Fujieda, Y.

AU - Otomo, Kotaro

AU - Horita, T.

AU - Oba, K.

AU - Kondo, M.

AU - Mukai, M.

AU - Yanai, M.

AU - Fukasawa, Y.

AU - Atsumi, T.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according to the International Society of Nephrology and Renal Pathology Society classification. This retrospective analysis comprised 186 Japanese patients given a diagnosis of LN by renal specimen with a mean observation period of 12 years. Primary end point was defined as death or end-stage renal disease, and standardized mortality ratios were calculated. Five patients presented with histopathological class I, 62 with II, 21 with III or IIIV, 73 with IV or IVV and 25 with V. Fourteen deaths occurred, corresponding to an overall standardized mortality ratio of 3.59 (95% confidence interval 2.02-5.81, p<0.0001). Kaplan-Meier analysis revealed a 10-year overall survival of 95.7%. Nephrotic proteinuria (≥3.5 g/day) at baseline was identified as an independent poor prognostic factor for overall survival in Cox regression analysis. Kaplan-Meier analysis revealed a 10-year renal survival as 94.3%. Male gender and nephrotic proteinuria at baseline were identified as independent poor prognostic factors for renal survival in Cox regression analysis. In conclusion, LN was associated with a 3.59-fold increase in mortality compared with the general population. Male gender and nephrotic proteinuria were predictive for poor renal outcome.

AB - The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according to the International Society of Nephrology and Renal Pathology Society classification. This retrospective analysis comprised 186 Japanese patients given a diagnosis of LN by renal specimen with a mean observation period of 12 years. Primary end point was defined as death or end-stage renal disease, and standardized mortality ratios were calculated. Five patients presented with histopathological class I, 62 with II, 21 with III or IIIV, 73 with IV or IVV and 25 with V. Fourteen deaths occurred, corresponding to an overall standardized mortality ratio of 3.59 (95% confidence interval 2.02-5.81, p<0.0001). Kaplan-Meier analysis revealed a 10-year overall survival of 95.7%. Nephrotic proteinuria (≥3.5 g/day) at baseline was identified as an independent poor prognostic factor for overall survival in Cox regression analysis. Kaplan-Meier analysis revealed a 10-year renal survival as 94.3%. Male gender and nephrotic proteinuria at baseline were identified as independent poor prognostic factors for renal survival in Cox regression analysis. In conclusion, LN was associated with a 3.59-fold increase in mortality compared with the general population. Male gender and nephrotic proteinuria were predictive for poor renal outcome.

KW - Nephritis

KW - Renal lupus

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=84928150388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928150388&partnerID=8YFLogxK

U2 - 10.1177/0961203314536246

DO - 10.1177/0961203314536246

M3 - Article

C2 - 24860121

AN - SCOPUS:84928150388

VL - 23

SP - 1124

EP - 1132

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 11

ER -