Long-term Outcomes of Laparoscopic Versus Open Surgery for Clinical Stage i Gastric Cancer: The LOC-1 Study

Michitaka Honda, Naoki Hiki, Takahiro Kinoshita, Hiroshi Yabusaki, Takayuki Abe, Souya Nunobe, Mitsumi Terada, Atsushi Matsuki, Hideki Sunagawa, Masaki Aizawa, Mark A. Healy, Manabu Iwasaki, Toshi A. Furukawa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Clinical trials comparing laparoscopic gastrectomy (LG) versus traditional open gastrectomy (OG) have been planned, their surgical outcomes reported but their oncologic outcomes are still pending. Consequently, we have conducted this large-scale historical cohort study to provide relevant information rapidly to guide our current practice. Methods: Through a consensus meeting involving surgeons, biostatisticians, and epidemiologists, 30 variables of preoperative information possibly influencing surgeons' choice between LG versus OG and potentially associating with outcomes were identified to enable rigorous estimation of propensity scores. A total of 4235 consecutive patients who underwent gastrectomy for gastric adenocarcinoma were identified and their relevant data were gathered from the participating hospitals. After propensity score matching, 1848 patients (924 each for LG and OG) were selected for comparison of long-term outcomes. Results: In the propensity-matched population, the 5-year overall survival was 96.3% [95% confidence interval (CI) 95.0-97.6] in the OG as compared with 97.1% (95% CI, 95.9-98.3) in LG. The number of all-cause death was 33/924 in the OG and 24/924 in the LG through the entire period, and the hazard ratio (LG/OG) for overall death was 0.75 (95% CI, 0.44-1.27; P = 0.290). The 3-year recurrence-free survival was 97.4% (95% CI, 96.4-98.5) in the OG and 97.7% (95% CI, 96.5-98.8) in the LG. The number of recurrence was 22/924 in the OG and 21/924 in the LG through the entire period, and the hazard ratio was 1.01 (95% CI, 0.55-1.84; P = 0.981). Conclusions: This observational study adjusted for all-known confounding factors seems to provide strong enough evidence to suggest that LG is oncologically comparable to OG for gastric cancer.

Original languageEnglish
Pages (from-to)214-222
Number of pages9
JournalAnnals of Surgery
Volume264
Issue number2
DOIs
Publication statusPublished - 2016 Aug 1

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Gastrectomy
Stomach Neoplasms
Confidence Intervals
Propensity Score
Recurrence
Survival

Keywords

  • gastric cancer
  • laparoscopic surgery
  • long-term outcome
  • propensity score matching

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Honda, M., Hiki, N., Kinoshita, T., Yabusaki, H., Abe, T., Nunobe, S., ... Furukawa, T. A. (2016). Long-term Outcomes of Laparoscopic Versus Open Surgery for Clinical Stage i Gastric Cancer: The LOC-1 Study. Annals of Surgery, 264(2), 214-222. https://doi.org/10.1097/SLA.0000000000001654

Long-term Outcomes of Laparoscopic Versus Open Surgery for Clinical Stage i Gastric Cancer : The LOC-1 Study. / Honda, Michitaka; Hiki, Naoki; Kinoshita, Takahiro; Yabusaki, Hiroshi; Abe, Takayuki; Nunobe, Souya; Terada, Mitsumi; Matsuki, Atsushi; Sunagawa, Hideki; Aizawa, Masaki; Healy, Mark A.; Iwasaki, Manabu; Furukawa, Toshi A.

In: Annals of Surgery, Vol. 264, No. 2, 01.08.2016, p. 214-222.

Research output: Contribution to journalArticle

Honda, M, Hiki, N, Kinoshita, T, Yabusaki, H, Abe, T, Nunobe, S, Terada, M, Matsuki, A, Sunagawa, H, Aizawa, M, Healy, MA, Iwasaki, M & Furukawa, TA 2016, 'Long-term Outcomes of Laparoscopic Versus Open Surgery for Clinical Stage i Gastric Cancer: The LOC-1 Study', Annals of Surgery, vol. 264, no. 2, pp. 214-222. https://doi.org/10.1097/SLA.0000000000001654
Honda, Michitaka ; Hiki, Naoki ; Kinoshita, Takahiro ; Yabusaki, Hiroshi ; Abe, Takayuki ; Nunobe, Souya ; Terada, Mitsumi ; Matsuki, Atsushi ; Sunagawa, Hideki ; Aizawa, Masaki ; Healy, Mark A. ; Iwasaki, Manabu ; Furukawa, Toshi A. / Long-term Outcomes of Laparoscopic Versus Open Surgery for Clinical Stage i Gastric Cancer : The LOC-1 Study. In: Annals of Surgery. 2016 ; Vol. 264, No. 2. pp. 214-222.
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AU - Honda, Michitaka

AU - Hiki, Naoki

AU - Kinoshita, Takahiro

AU - Yabusaki, Hiroshi

AU - Abe, Takayuki

AU - Nunobe, Souya

AU - Terada, Mitsumi

AU - Matsuki, Atsushi

AU - Sunagawa, Hideki

AU - Aizawa, Masaki

AU - Healy, Mark A.

AU - Iwasaki, Manabu

AU - Furukawa, Toshi A.

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N2 - Background: Clinical trials comparing laparoscopic gastrectomy (LG) versus traditional open gastrectomy (OG) have been planned, their surgical outcomes reported but their oncologic outcomes are still pending. Consequently, we have conducted this large-scale historical cohort study to provide relevant information rapidly to guide our current practice. Methods: Through a consensus meeting involving surgeons, biostatisticians, and epidemiologists, 30 variables of preoperative information possibly influencing surgeons' choice between LG versus OG and potentially associating with outcomes were identified to enable rigorous estimation of propensity scores. A total of 4235 consecutive patients who underwent gastrectomy for gastric adenocarcinoma were identified and their relevant data were gathered from the participating hospitals. After propensity score matching, 1848 patients (924 each for LG and OG) were selected for comparison of long-term outcomes. Results: In the propensity-matched population, the 5-year overall survival was 96.3% [95% confidence interval (CI) 95.0-97.6] in the OG as compared with 97.1% (95% CI, 95.9-98.3) in LG. The number of all-cause death was 33/924 in the OG and 24/924 in the LG through the entire period, and the hazard ratio (LG/OG) for overall death was 0.75 (95% CI, 0.44-1.27; P = 0.290). The 3-year recurrence-free survival was 97.4% (95% CI, 96.4-98.5) in the OG and 97.7% (95% CI, 96.5-98.8) in the LG. The number of recurrence was 22/924 in the OG and 21/924 in the LG through the entire period, and the hazard ratio was 1.01 (95% CI, 0.55-1.84; P = 0.981). Conclusions: This observational study adjusted for all-known confounding factors seems to provide strong enough evidence to suggest that LG is oncologically comparable to OG for gastric cancer.

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