Long-term prognosis in ischemic cerebrovascular disease in relation to cerebral blood flow and metabolism

Hisao Tachibana, Fumio Gotoh, Shin Ichiro Ebihara, Hiroyuki Okayasu, Yasuhisa Kitagawa, Norihiro Suzuki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The correlation between long-term prognosis and cerebral hemodynamics and oxygen consumption was investigated in 46 patients with ischemic supratentorial cerebrovascular disease. Cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2) were measured by the N2O method 1-6 months (mean 68 days) after disease onset. No significant correlation was observed among CBF, CMRO2 and activities of daily living at the time of measurement. The patients' physical condition was reevaluated by the questionnaire method 2 years or more (mean 53 months) later. The CBF values in patients who were independent after completion of the follow-up period significantly exceeded those of patients dying during the period (P < 0.05). No correlation was observed in CMRO2. The relationship among CBF, CMRO2 and changes in physical condition during the period was evaluated. Mean CBF values in patients with better prognosis exceeded those of patients with poor prognosis. Notably, CBF values in the "improved" group significantly exceeded those in the "unchanged" or "died" group (P < 0.05, P < 0.01). CMRO2 was not significantly correlated with changes of physical condition. These results emphasize the importance of total CBF for long-term prognosis and indicate that flow values, rather than metabolic indices, obtained in the chronic stage can usefully predict the long-term prognosis.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
JournalJournal of the Neurological Sciences
Volume56
Issue number2-3
DOIs
Publication statusPublished - 1982

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Cerebrovascular Circulation
Cerebrovascular Disorders
Oxygen Consumption
Activities of Daily Living
Hemodynamics

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Long-term prognosis in ischemic cerebrovascular disease in relation to cerebral blood flow and metabolism. / Tachibana, Hisao; Gotoh, Fumio; Ebihara, Shin Ichiro; Okayasu, Hiroyuki; Kitagawa, Yasuhisa; Suzuki, Norihiro.

In: Journal of the Neurological Sciences, Vol. 56, No. 2-3, 1982, p. 357-364.

Research output: Contribution to journalArticle

Tachibana, Hisao ; Gotoh, Fumio ; Ebihara, Shin Ichiro ; Okayasu, Hiroyuki ; Kitagawa, Yasuhisa ; Suzuki, Norihiro. / Long-term prognosis in ischemic cerebrovascular disease in relation to cerebral blood flow and metabolism. In: Journal of the Neurological Sciences. 1982 ; Vol. 56, No. 2-3. pp. 357-364.
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