Abstract
We report on the long-term follow-up of 15 patients with steroid-dependent sensorineural hearing loss (SDSNHL), which was steroid dose dependent. We classified the patients into 2 groups: group A consisted of 6 patients with systemic SDSNHL, and group B consisted of 9 patients with inner-ear-specific SDSNHL without systemic disease. Group B patients were further classified as patients with slowly or rapidly progressive hearing loss. The yearly rate of hearing deterioration was greater in group B than in group A. Thus, the long-term hearing prognosis of patients in group B was worse than those in group A. Although SDSNHL may have immune-related origins, we hypothesize that hearing deterioration may be caused by proinflammatory cytokines because many of our cases exhibited abnormal immunological laboratory values and because many of these cases responded favorably to steroid treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 26-34 |
| Number of pages | 9 |
| Journal | Audiology and Neurotology |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2008 Dec |
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Keywords
- Long-term prognosis
- Steroid-dependent sensorineural hearing loss
- Takayasu's arteritis
ASJC Scopus subject areas
- Physiology
- Otorhinolaryngology
- Sensory Systems
- Speech and Hearing
Cite this
Long-term prognosis of steroid-dependent sensorineural hearing loss. / Kanzaki, Jin; Kanzaki, Sho; Ogawa, Kaoru.
In: Audiology and Neurotology, Vol. 14, No. 1, 12.2008, p. 26-34.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term prognosis of steroid-dependent sensorineural hearing loss
AU - Kanzaki, Jin
AU - Kanzaki, Sho
AU - Ogawa, Kaoru
PY - 2008/12
Y1 - 2008/12
N2 - We report on the long-term follow-up of 15 patients with steroid-dependent sensorineural hearing loss (SDSNHL), which was steroid dose dependent. We classified the patients into 2 groups: group A consisted of 6 patients with systemic SDSNHL, and group B consisted of 9 patients with inner-ear-specific SDSNHL without systemic disease. Group B patients were further classified as patients with slowly or rapidly progressive hearing loss. The yearly rate of hearing deterioration was greater in group B than in group A. Thus, the long-term hearing prognosis of patients in group B was worse than those in group A. Although SDSNHL may have immune-related origins, we hypothesize that hearing deterioration may be caused by proinflammatory cytokines because many of our cases exhibited abnormal immunological laboratory values and because many of these cases responded favorably to steroid treatment.
AB - We report on the long-term follow-up of 15 patients with steroid-dependent sensorineural hearing loss (SDSNHL), which was steroid dose dependent. We classified the patients into 2 groups: group A consisted of 6 patients with systemic SDSNHL, and group B consisted of 9 patients with inner-ear-specific SDSNHL without systemic disease. Group B patients were further classified as patients with slowly or rapidly progressive hearing loss. The yearly rate of hearing deterioration was greater in group B than in group A. Thus, the long-term hearing prognosis of patients in group B was worse than those in group A. Although SDSNHL may have immune-related origins, we hypothesize that hearing deterioration may be caused by proinflammatory cytokines because many of our cases exhibited abnormal immunological laboratory values and because many of these cases responded favorably to steroid treatment.
KW - Long-term prognosis
KW - Steroid-dependent sensorineural hearing loss
KW - Takayasu's arteritis
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UR - http://www.scopus.com/inward/citedby.url?scp=49949102393&partnerID=8YFLogxK
U2 - 10.1159/000151587
DO - 10.1159/000151587
M3 - Article
C2 - 18728359
AN - SCOPUS:49949102393
VL - 14
SP - 26
EP - 34
JO - Audiology and Neurotology
JF - Audiology and Neurotology
SN - 1420-3030
IS - 1
ER -