Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population

Kazumasa Miki, Mitsuhiro Fujishiro, Shinya Kodashima, Naohisa Yahagi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Aim : In order to reduce gastric cancer death, mass screening for gastric cancer has been established in Japan for several decades. Only photofluorography is considered to be an acceptable screening method so far, but recent evidence may show the usefulness of serum pepsinogen (PG) measurement for gastric cancer screening. The aim of the present study was to elucidate the feasibility of measuring serum PG levels for detection of gastric cancers. Methods : Serum PG levels (PG I /PG II ) were measured in asymptomatic middle-aged Japanese between 1991 and 2005. Those with a PG I ≤70 ng/mL and PG I /PG II ≤3 were defined as having a positive PG test. According to the obtained results of serum PG levels and previous individual records, those with a positive PG test and those with a negative PG test took gastroendoscopy every 2 and 5 years, respectively. Results : The total number of participating individuals was 101 892 (mean age of 48.7 years). In a total of 21 178 planned gastroendoscopies (20.8%), 13 789 (65.1%) underwent gastroendoscopy and 125 gastric cancers were detected, which corresponded to 0.12% of all participants and to 0.91% of those with gastroendoscopy. Early-stage cancers and intestinal-type intramucosal cancers accounted for 80% and 39% of all the detected cancers, respectively. Conclusions : Serum PG measurement for mass screening of gastric cancer enabled us to achieve high recruitment for gastroendoscopy in intended individuals, a favorable detection rate of gastric cancer and, in particular, an extremely high proportion of early-stage gastric cancer in all the detected cancers.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalGastroenterological Endoscopy
Volume52
Issue number3
Publication statusPublished - 2010 Mar
Externally publishedYes

Fingerprint

Pepsinogen A
Early Detection of Cancer
Stomach Neoplasms
Serum
Population
Pepsinogen C
Mass Screening
Photofluorography
Intestinal Neoplasms
Neoplasms
Japan

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population. / Miki, Kazumasa; Fujishiro, Mitsuhiro; Kodashima, Shinya; Yahagi, Naohisa.

In: Gastroenterological Endoscopy, Vol. 52, No. 3, 03.2010, p. 450-454.

Research output: Contribution to journalArticle

@article{b48a119cf87848229aa732d835ca8a91,
title = "Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population",
abstract = "Background and Aim : In order to reduce gastric cancer death, mass screening for gastric cancer has been established in Japan for several decades. Only photofluorography is considered to be an acceptable screening method so far, but recent evidence may show the usefulness of serum pepsinogen (PG) measurement for gastric cancer screening. The aim of the present study was to elucidate the feasibility of measuring serum PG levels for detection of gastric cancers. Methods : Serum PG levels (PG I /PG II ) were measured in asymptomatic middle-aged Japanese between 1991 and 2005. Those with a PG I ≤70 ng/mL and PG I /PG II ≤3 were defined as having a positive PG test. According to the obtained results of serum PG levels and previous individual records, those with a positive PG test and those with a negative PG test took gastroendoscopy every 2 and 5 years, respectively. Results : The total number of participating individuals was 101 892 (mean age of 48.7 years). In a total of 21 178 planned gastroendoscopies (20.8{\%}), 13 789 (65.1{\%}) underwent gastroendoscopy and 125 gastric cancers were detected, which corresponded to 0.12{\%} of all participants and to 0.91{\%} of those with gastroendoscopy. Early-stage cancers and intestinal-type intramucosal cancers accounted for 80{\%} and 39{\%} of all the detected cancers, respectively. Conclusions : Serum PG measurement for mass screening of gastric cancer enabled us to achieve high recruitment for gastroendoscopy in intended individuals, a favorable detection rate of gastric cancer and, in particular, an extremely high proportion of early-stage gastric cancer in all the detected cancers.",
author = "Kazumasa Miki and Mitsuhiro Fujishiro and Shinya Kodashima and Naohisa Yahagi",
year = "2010",
month = "3",
language = "English",
volume = "52",
pages = "450--454",
journal = "Gastroenterological Endoscopy",
issn = "0387-1207",
publisher = "Japan Gastroenterological Endoscopy Society",
number = "3",

}

TY - JOUR

T1 - Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population

AU - Miki, Kazumasa

AU - Fujishiro, Mitsuhiro

AU - Kodashima, Shinya

AU - Yahagi, Naohisa

PY - 2010/3

Y1 - 2010/3

N2 - Background and Aim : In order to reduce gastric cancer death, mass screening for gastric cancer has been established in Japan for several decades. Only photofluorography is considered to be an acceptable screening method so far, but recent evidence may show the usefulness of serum pepsinogen (PG) measurement for gastric cancer screening. The aim of the present study was to elucidate the feasibility of measuring serum PG levels for detection of gastric cancers. Methods : Serum PG levels (PG I /PG II ) were measured in asymptomatic middle-aged Japanese between 1991 and 2005. Those with a PG I ≤70 ng/mL and PG I /PG II ≤3 were defined as having a positive PG test. According to the obtained results of serum PG levels and previous individual records, those with a positive PG test and those with a negative PG test took gastroendoscopy every 2 and 5 years, respectively. Results : The total number of participating individuals was 101 892 (mean age of 48.7 years). In a total of 21 178 planned gastroendoscopies (20.8%), 13 789 (65.1%) underwent gastroendoscopy and 125 gastric cancers were detected, which corresponded to 0.12% of all participants and to 0.91% of those with gastroendoscopy. Early-stage cancers and intestinal-type intramucosal cancers accounted for 80% and 39% of all the detected cancers, respectively. Conclusions : Serum PG measurement for mass screening of gastric cancer enabled us to achieve high recruitment for gastroendoscopy in intended individuals, a favorable detection rate of gastric cancer and, in particular, an extremely high proportion of early-stage gastric cancer in all the detected cancers.

AB - Background and Aim : In order to reduce gastric cancer death, mass screening for gastric cancer has been established in Japan for several decades. Only photofluorography is considered to be an acceptable screening method so far, but recent evidence may show the usefulness of serum pepsinogen (PG) measurement for gastric cancer screening. The aim of the present study was to elucidate the feasibility of measuring serum PG levels for detection of gastric cancers. Methods : Serum PG levels (PG I /PG II ) were measured in asymptomatic middle-aged Japanese between 1991 and 2005. Those with a PG I ≤70 ng/mL and PG I /PG II ≤3 were defined as having a positive PG test. According to the obtained results of serum PG levels and previous individual records, those with a positive PG test and those with a negative PG test took gastroendoscopy every 2 and 5 years, respectively. Results : The total number of participating individuals was 101 892 (mean age of 48.7 years). In a total of 21 178 planned gastroendoscopies (20.8%), 13 789 (65.1%) underwent gastroendoscopy and 125 gastric cancers were detected, which corresponded to 0.12% of all participants and to 0.91% of those with gastroendoscopy. Early-stage cancers and intestinal-type intramucosal cancers accounted for 80% and 39% of all the detected cancers, respectively. Conclusions : Serum PG measurement for mass screening of gastric cancer enabled us to achieve high recruitment for gastroendoscopy in intended individuals, a favorable detection rate of gastric cancer and, in particular, an extremely high proportion of early-stage gastric cancer in all the detected cancers.

UR - http://www.scopus.com/inward/record.url?scp=77951279010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951279010&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77951279010

VL - 52

SP - 450

EP - 454

JO - Gastroenterological Endoscopy

JF - Gastroenterological Endoscopy

SN - 0387-1207

IS - 3

ER -