Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics

Hiroyuki Uchida, Ariel Graff-Guerrero, Benoit H. Mulsant, Bruce G. Pollock, David C. Mamo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: While antipsychotic-free schizophrenia patients showed a high degree of within-subject variability in dopamine D2 receptor density over 6-24 months, no study has examined the long-term stability of D2 receptor measures in medicated patients. Methods: Four schizophrenia patients receiving a stable dose of risperidone underwent [11C]raclopride positron emission tomography scans on two occasions 5-14 months apart. Results: Plasma risperidone levels were found to be consistent between scans, and consistencies of nondisplaceable D2 binding potential and D2 occupancy were good. Conclusions: The finding supports the validity of quantification of D2 receptor binding in longitudinal PET studies of medicated patients with schizophrenia.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalSchizophrenia Research
Volume109
Issue number1-3
DOIs
Publication statusPublished - 2009 Apr 1
Externally publishedYes

Keywords

  • Antipsychotic
  • Dopamine
  • Dopamine D receptor
  • PET
  • Risperidone
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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