Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics

Hiroyuki Uchida, Ariel Graff-Guerrero, Benoit H. Mulsant, Bruce G. Pollock, David C. Mamo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: While antipsychotic-free schizophrenia patients showed a high degree of within-subject variability in dopamine D2 receptor density over 6-24 months, no study has examined the long-term stability of D2 receptor measures in medicated patients. Methods: Four schizophrenia patients receiving a stable dose of risperidone underwent [11C]raclopride positron emission tomography scans on two occasions 5-14 months apart. Results: Plasma risperidone levels were found to be consistent between scans, and consistencies of nondisplaceable D2 binding potential and D2 occupancy were good. Conclusions: The finding supports the validity of quantification of D2 receptor binding in longitudinal PET studies of medicated patients with schizophrenia.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalSchizophrenia Research
Volume109
Issue number1-3
DOIs
Publication statusPublished - 2009 Apr
Externally publishedYes

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Antipsychotic Agents
Schizophrenia
Risperidone
Raclopride
Dopamine D2 Receptors
Positron-Emission Tomography
Longitudinal Studies

Keywords

  • Antipsychotic
  • Dopamine
  • Dopamine D receptor
  • PET
  • Risperidone
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics. / Uchida, Hiroyuki; Graff-Guerrero, Ariel; Mulsant, Benoit H.; Pollock, Bruce G.; Mamo, David C.

In: Schizophrenia Research, Vol. 109, No. 1-3, 04.2009, p. 130-133.

Research output: Contribution to journalArticle

Uchida, Hiroyuki ; Graff-Guerrero, Ariel ; Mulsant, Benoit H. ; Pollock, Bruce G. ; Mamo, David C. / Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics. In: Schizophrenia Research. 2009 ; Vol. 109, No. 1-3. pp. 130-133.
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