Abstract
Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5% at 5 years and 29.6% at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.
| Original language | English |
|---|---|
| Pages (from-to) | 152-155 |
| Number of pages | 4 |
| Journal | European Journal of Cardio-thoracic Surgery |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1998 Aug |
| Externally published | Yes |
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Keywords
- cNO-pN2 disease
- Long-term survivors
- Non-small cell lung cancer
- pN2-disease
- Systematic mediastinal node dissection
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection. / Yano, Tokujiro; Fukuyama, Yasuro; Yokoyama, Hideki; Kuninaka, Shinji; Terazaki, Yasuhiro; Uehara, Tadashi; Asoh, Hiroshi; Ichinose, Yukito.
In: European Journal of Cardio-thoracic Surgery, Vol. 14, No. 2, 08.1998, p. 152-155.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection
AU - Yano, Tokujiro
AU - Fukuyama, Yasuro
AU - Yokoyama, Hideki
AU - Kuninaka, Shinji
AU - Terazaki, Yasuhiro
AU - Uehara, Tadashi
AU - Asoh, Hiroshi
AU - Ichinose, Yukito
PY - 1998/8
Y1 - 1998/8
N2 - Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5% at 5 years and 29.6% at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.
AB - Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5% at 5 years and 29.6% at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.
KW - cNO-pN2 disease
KW - Long-term survivors
KW - Non-small cell lung cancer
KW - pN2-disease
KW - Systematic mediastinal node dissection
UR - http://www.scopus.com/inward/record.url?scp=0031707091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031707091&partnerID=8YFLogxK
U2 - 10.1016/S1010-7940(98)00162-6
DO - 10.1016/S1010-7940(98)00162-6
M3 - Article
C2 - 9755000
AN - SCOPUS:0031707091
VL - 14
SP - 152
EP - 155
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
SN - 1010-7940
IS - 2
ER -