Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection

Tokujiro Yano, Yasuro Fukuyama, Hideki Yokoyama, Shinji Kuninaka, Yasuhiro Terazaki, Tadashi Uehara, Hiroshi Asoh, Yukito Ichinose

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5% at 5 years and 29.6% at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalEuropean Journal of Cardio-thoracic Surgery
Volume14
Issue number2
DOIs
Publication statusPublished - 1998 Aug
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Survivors
Dissection
Neoplasm Metastasis
Lymph Node Excision
Survival Rate
Recurrence
Population

Keywords

  • cNO-pN2 disease
  • Long-term survivors
  • Non-small cell lung cancer
  • pN2-disease
  • Systematic mediastinal node dissection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection. / Yano, Tokujiro; Fukuyama, Yasuro; Yokoyama, Hideki; Kuninaka, Shinji; Terazaki, Yasuhiro; Uehara, Tadashi; Asoh, Hiroshi; Ichinose, Yukito.

In: European Journal of Cardio-thoracic Surgery, Vol. 14, No. 2, 08.1998, p. 152-155.

Research output: Contribution to journalArticle

Yano, Tokujiro ; Fukuyama, Yasuro ; Yokoyama, Hideki ; Kuninaka, Shinji ; Terazaki, Yasuhiro ; Uehara, Tadashi ; Asoh, Hiroshi ; Ichinose, Yukito. / Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection. In: European Journal of Cardio-thoracic Surgery. 1998 ; Vol. 14, No. 2. pp. 152-155.
@article{0db93e8136e14c24b9d00cd1d9f139f2,
title = "Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection",
abstract = "Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5{\%} at 5 years and 29.6{\%} at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.",
keywords = "cNO-pN2 disease, Long-term survivors, Non-small cell lung cancer, pN2-disease, Systematic mediastinal node dissection",
author = "Tokujiro Yano and Yasuro Fukuyama and Hideki Yokoyama and Shinji Kuninaka and Yasuhiro Terazaki and Tadashi Uehara and Hiroshi Asoh and Yukito Ichinose",
year = "1998",
month = "8",
doi = "10.1016/S1010-7940(98)00162-6",
language = "English",
volume = "14",
pages = "152--155",
journal = "European Journal of Cardio-thoracic Surgery",
issn = "1010-7940",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Long-term survivors with pN2 non-small cell lung cancer after a complete resection with a systematic mediastinal node dissection

AU - Yano, Tokujiro

AU - Fukuyama, Yasuro

AU - Yokoyama, Hideki

AU - Kuninaka, Shinji

AU - Terazaki, Yasuhiro

AU - Uehara, Tadashi

AU - Asoh, Hiroshi

AU - Ichinose, Yukito

PY - 1998/8

Y1 - 1998/8

N2 - Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5% at 5 years and 29.6% at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.

AB - Objective: A substantial number of surgical patients with pN2 disease have survived longer than 5 years without any evidence of recurrence, although the surgical indications for those patients remain controversial. The present study was performed in order to clarify the clinical characteristics of the long-term survivors with pN2 disease. Methods: We retrospectively reviewed the cases of 111 patients with pN2 disease who had undergone a complete resection with a systematic mediastinal lymph node dissection from 1974 through 1991. Results: Of the 111 patients with pN2 disease, 20 survived longer than 5 years after a surgical resection. When both the pre- and postoperative conditions were compared between the long- term survivors and the others, the long-term survivors were characterized by significantly higher proportions of cN0 disease (P = 0.031), pT1 disease (P = 0.004), skip metastasis without hilar node metastasis (P = 0.028), and metastasis of a single mediastinal station (0.044). Of those characteristics, only the likelihood of having cN0 disease could be pre-operatively determined. The survival rate of such a population with cN0-pN2 disease was 34.5% at 5 years and 29.6% at 10 years after a complete resection, respectively. Conclusions: Pathologic N2 patients with some favorable prognostic factors can survive long-term after a complete resection combined with a systematic mediastinal lymph node dissection. At present, due to the lack of any effective adjuvant therapy, a systematic mediastinal node dissection should be routinely performed even in patients with cNO disease.

KW - cNO-pN2 disease

KW - Long-term survivors

KW - Non-small cell lung cancer

KW - pN2-disease

KW - Systematic mediastinal node dissection

UR - http://www.scopus.com/inward/record.url?scp=0031707091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031707091&partnerID=8YFLogxK

U2 - 10.1016/S1010-7940(98)00162-6

DO - 10.1016/S1010-7940(98)00162-6

M3 - Article

C2 - 9755000

AN - SCOPUS:0031707091

VL - 14

SP - 152

EP - 155

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 2

ER -