Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response

Daniel L. Alkon, Juan Vicente Sánchez-Andrés, Etsuro Ito, Kotaro Oka, Tohru Yoshioka, Carlos Collin

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous γ-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and voltage-clamp experiments suggest that this synaptic transformation is due to a shift from a net increase of conductance to a net decrease of conductance in response to GABA. GABA-induced elevation of intracellular calcium is prolonged after the same stimulus pairing and may, therefore, contribute to this synaptic transformation via Ca2+-activated phosphorylation pathways. This synaptic transformation, which does not follow unpaired stimulus presentations, occurs in a neuronal compartment spatially separated from the soma, which also changes during stimulus pairing.

Original languageEnglish
Pages (from-to)11862-11866
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number24
Publication statusPublished - 1992
Externally publishedYes

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gamma-Aminobutyric Acid
Aminobutyrates
Carisoprodol
Membrane Potentials
Phosphorylation
Calcium

Keywords

  • Associative learning
  • Ca imaging
  • Cl channel
  • Hermissenda
  • K channel

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response. / Alkon, Daniel L.; Sánchez-Andrés, Juan Vicente; Ito, Etsuro; Oka, Kotaro; Yoshioka, Tohru; Collin, Carlos.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 24, 1992, p. 11862-11866.

Research output: Contribution to journalArticle

Alkon, Daniel L. ; Sánchez-Andrés, Juan Vicente ; Ito, Etsuro ; Oka, Kotaro ; Yoshioka, Tohru ; Collin, Carlos. / Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response. In: Proceedings of the National Academy of Sciences of the United States of America. 1992 ; Vol. 89, No. 24. pp. 11862-11866.
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