Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population

The Suita Study

Soshiro Ogata, Makoto Watanabe, Yoshihiro Kokubo, Aya Higashiyama, Yoko M. Nakao, Misa Takegami, Kunihiro Nishimura, Michikazu Nakai, Eri Kiyoshige, Kiminori Hosoda, Tomonori Okamura, Yoshihiro Miyamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Few previous studies used information on changes in fasting plasma glucose ( FPG ) assessed at multiple points in time in relationship to cardiovascular disease ( CVD ) incidence. The present study aimed to identify subgroups of FPG trajectories with assessing CVD incidence. Methods and Results The present study was based on the Suita study, a population-based cohort study in Japan. The primary outcome was incidence of the first CVD events consisting of stroke and coronary heart diseases between 1989 and 2013. The main exposure was FPG assessed every 2 years. We used joint latent class mixed models to derive FPG trajectories over time while evaluating cumulative incidence of CVD , and categorized participants into several subgroups based on those trajectories and cumulative incidence. We observed 356 and 243 CVD events during the median follow-up of 17.2 and 20.2 years among 3120 men and 3482 women, respectively. The joint latent mixed models found 3 subgroups in men and 2 subgroups in women. Of the 3 subgroups in men, 1 subgroup had FPG levels that increased sharply (96.5-205.0 mg/dL from aged 40 to 80 years) and higher CVD cumulative incidence. Of the 2 subgroups in women, 1 subgroup had FPG levels that increased sharply (97.7-190.5 mg/dL from aged 40 to 80 years) and tended to have slightly higher CVD incidence compared with the other subgroup. Conclusion It can be important to manage CVD risk factors especially for people whose FPG trajectories sharply increased to prevent CVD .

Original languageEnglish
Pages (from-to)e010628
JournalJournal of the American Heart Association
Volume8
Issue number3
DOIs
Publication statusPublished - 2019 Feb 5

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Fasting
Cardiovascular Diseases
Glucose
Population
Incidence
Joints
Coronary Disease
Japan
Cohort Studies
Stroke

Keywords

  • blood glucose trajectory
  • cardiovascular diseases
  • epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population : The Suita Study. / Ogata, Soshiro; Watanabe, Makoto; Kokubo, Yoshihiro; Higashiyama, Aya; Nakao, Yoko M.; Takegami, Misa; Nishimura, Kunihiro; Nakai, Michikazu; Kiyoshige, Eri; Hosoda, Kiminori; Okamura, Tomonori; Miyamoto, Yoshihiro.

In: Journal of the American Heart Association, Vol. 8, No. 3, 05.02.2019, p. e010628.

Research output: Contribution to journalArticle

Ogata, Soshiro ; Watanabe, Makoto ; Kokubo, Yoshihiro ; Higashiyama, Aya ; Nakao, Yoko M. ; Takegami, Misa ; Nishimura, Kunihiro ; Nakai, Michikazu ; Kiyoshige, Eri ; Hosoda, Kiminori ; Okamura, Tomonori ; Miyamoto, Yoshihiro. / Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population : The Suita Study. In: Journal of the American Heart Association. 2019 ; Vol. 8, No. 3. pp. e010628.
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AU - Kokubo, Yoshihiro

AU - Higashiyama, Aya

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AU - Takegami, Misa

AU - Nishimura, Kunihiro

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N2 - Background Few previous studies used information on changes in fasting plasma glucose ( FPG ) assessed at multiple points in time in relationship to cardiovascular disease ( CVD ) incidence. The present study aimed to identify subgroups of FPG trajectories with assessing CVD incidence. Methods and Results The present study was based on the Suita study, a population-based cohort study in Japan. The primary outcome was incidence of the first CVD events consisting of stroke and coronary heart diseases between 1989 and 2013. The main exposure was FPG assessed every 2 years. We used joint latent class mixed models to derive FPG trajectories over time while evaluating cumulative incidence of CVD , and categorized participants into several subgroups based on those trajectories and cumulative incidence. We observed 356 and 243 CVD events during the median follow-up of 17.2 and 20.2 years among 3120 men and 3482 women, respectively. The joint latent mixed models found 3 subgroups in men and 2 subgroups in women. Of the 3 subgroups in men, 1 subgroup had FPG levels that increased sharply (96.5-205.0 mg/dL from aged 40 to 80 years) and higher CVD cumulative incidence. Of the 2 subgroups in women, 1 subgroup had FPG levels that increased sharply (97.7-190.5 mg/dL from aged 40 to 80 years) and tended to have slightly higher CVD incidence compared with the other subgroup. Conclusion It can be important to manage CVD risk factors especially for people whose FPG trajectories sharply increased to prevent CVD .

AB - Background Few previous studies used information on changes in fasting plasma glucose ( FPG ) assessed at multiple points in time in relationship to cardiovascular disease ( CVD ) incidence. The present study aimed to identify subgroups of FPG trajectories with assessing CVD incidence. Methods and Results The present study was based on the Suita study, a population-based cohort study in Japan. The primary outcome was incidence of the first CVD events consisting of stroke and coronary heart diseases between 1989 and 2013. The main exposure was FPG assessed every 2 years. We used joint latent class mixed models to derive FPG trajectories over time while evaluating cumulative incidence of CVD , and categorized participants into several subgroups based on those trajectories and cumulative incidence. We observed 356 and 243 CVD events during the median follow-up of 17.2 and 20.2 years among 3120 men and 3482 women, respectively. The joint latent mixed models found 3 subgroups in men and 2 subgroups in women. Of the 3 subgroups in men, 1 subgroup had FPG levels that increased sharply (96.5-205.0 mg/dL from aged 40 to 80 years) and higher CVD cumulative incidence. Of the 2 subgroups in women, 1 subgroup had FPG levels that increased sharply (97.7-190.5 mg/dL from aged 40 to 80 years) and tended to have slightly higher CVD incidence compared with the other subgroup. Conclusion It can be important to manage CVD risk factors especially for people whose FPG trajectories sharply increased to prevent CVD .

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