TY - JOUR
T1 - Longitudinal trends in blood pressure associated with the frequency of laughter
T2 - The circulatory risk in communities study (circs), a longitudinal study of the japanese general population
AU - for the CIRCS Investigators
AU - Ikeda, Satomi
AU - Ikeda, Ai
AU - Yamagishi, Kazumasa
AU - Hori, Miyuki
AU - Kubo, Sachimi
AU - Sata, Mizuki
AU - Okada, Chika
AU - Umesawa, Mitsumasa
AU - Sankai, Tomoko
AU - Kitamura, Akihiko
AU - Kiyama, Masahiko
AU - Ohira, Tetsuya
AU - Tanigawa, Takeshi
AU - Iso, Hiroyasu
N1 - Funding Information:
This study was supported by Health Labour Sciences Research Grant, Comprehensive Research on Lifestyle Diseases (H25-Junkanki(Syosyu)-Ippan-008) from the Ministry of Health, Labour and Welfare, Japan; and the Japan Agency for Medical Research and Development (15ek0210003h0003), Japan. Conflicts of interest: None declared.
Publisher Copyright:
© 2020 Satomi Ikeda et al.
PY - 2021
Y1 - 2021
N2 - Background: The frequency of laughter has been associated with cardiovascular disease and related biomarkers, but no previous studies have examined association between laughter and changes in blood pressure levels. We sought to identify temporal relationships between frequency of laughter in daily life and systolic and diastolic blood pressure changes in participants from 2010 through 2014. Methods: Participants were 554 men and 887 women aged 40–74 years who answered self-administered questionnaire quantifying frequency of laughter at baseline. We measured participant blood pressure levels twice using automated sphygmomanometers for each year from 2010 to 2014. The associations between laughter and changes in blood pressure over time were analyzed using linear mixed-effect models. Results: There was no significant difference in blood pressure according to frequency of laughter at baseline in either sex. Men with frequency of laughter 1 to 3 per month or almost never had significantly increased systolic and diastolic blood pressure levels over the 4-year period (time-dependent difference: 0.96 mm Hg (95% confidence interval [CI], −0.2 to 1.8; P = 0.05). Changes in blood pressure associated with infrequent laughter (ie, 1 to 3 per month or almost never) were evident in men without antihypertensive medication use over 4 years (0.94 mm Hg; 95% CI, −0.2 to 2.0; P = 0.09) and men who were current drinkers at baseline (1.29 mm Hg; 95% CI, −0.1 to 2.3; P = 0.04). No significant difference was found between frequency of laughter and systolic (0.23 mm Hg; 95% CI, −1.0 to 1.5; P = 0.72) and diastolic (−0.07 mm Hg; 95% CI, −0.8 to 0.7; P = 0.86) blood pressure changes in women. Conclusions: Infrequent laughter was associated with long-term blood pressure increment among middle-aged men.
AB - Background: The frequency of laughter has been associated with cardiovascular disease and related biomarkers, but no previous studies have examined association between laughter and changes in blood pressure levels. We sought to identify temporal relationships between frequency of laughter in daily life and systolic and diastolic blood pressure changes in participants from 2010 through 2014. Methods: Participants were 554 men and 887 women aged 40–74 years who answered self-administered questionnaire quantifying frequency of laughter at baseline. We measured participant blood pressure levels twice using automated sphygmomanometers for each year from 2010 to 2014. The associations between laughter and changes in blood pressure over time were analyzed using linear mixed-effect models. Results: There was no significant difference in blood pressure according to frequency of laughter at baseline in either sex. Men with frequency of laughter 1 to 3 per month or almost never had significantly increased systolic and diastolic blood pressure levels over the 4-year period (time-dependent difference: 0.96 mm Hg (95% confidence interval [CI], −0.2 to 1.8; P = 0.05). Changes in blood pressure associated with infrequent laughter (ie, 1 to 3 per month or almost never) were evident in men without antihypertensive medication use over 4 years (0.94 mm Hg; 95% CI, −0.2 to 2.0; P = 0.09) and men who were current drinkers at baseline (1.29 mm Hg; 95% CI, −0.1 to 2.3; P = 0.04). No significant difference was found between frequency of laughter and systolic (0.23 mm Hg; 95% CI, −1.0 to 1.5; P = 0.72) and diastolic (−0.07 mm Hg; 95% CI, −0.8 to 0.7; P = 0.86) blood pressure changes in women. Conclusions: Infrequent laughter was associated with long-term blood pressure increment among middle-aged men.
KW - Blood pressure
KW - Cardiovascular-related biomarker
KW - Laughter frequency
KW - Longitudinal study
KW - Stress
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U2 - 10.2188/jea.JE20190140
DO - 10.2188/jea.JE20190140
M3 - Article
C2 - 32092749
AN - SCOPUS:85101745278
VL - 31
SP - 125
EP - 131
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 2
ER -