Loss of cholinergic synapses on the spinal motor neurons of amyotrophic lateral sclerosis

Masahiro Nagao, Hidemi Misawa, Shuichi Kato, Shunsaku Hirai

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The expression of vesicular acetylcholine transporter (VAChT) was examined immunohistochemically in the cholinergic synapses on the spinal motor neuron of the patient with sporadic amyotrophic lateral sclerosis (SALS). VAChT immunoreactive synapses were depleted on surviving motor neurons in SALS, while synaptophysin immunoreactivity was undiminished on the same neurons. This discrepancy suggests that in SALS, loss of cholinergic input on lower motor neurons is an early event, and may be part of the cause of death of those motor neurons.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalJournal of Neuropathology and Experimental Neurology
Volume57
Issue number4
DOIs
Publication statusPublished - 1998 Apr

Keywords

  • Axon collateral
  • C-bouton
  • Excitotoxicity
  • Inhibitory synapse
  • Interneuron
  • Motor cortex

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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