@article{759e2234c4b04b079c91d5fe38ec0e7b,
title = "Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia",
abstract = "We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line-derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells.",
author = "Takaharu Taketomi and Daigo Yoshiga and Koji Taniguchi and Takashi Kobayashi and Atsushi Nonami and Reiko Kato and Mika Sasaki and Atsuo Sasaki and Hitoshi Ishibashi and Maiko Moriyama and Nakamura, {Kei Ichiro} and Junji Nishimura and Akihiko Yoshimura",
note = "Funding Information: We thank T. Yoshioka, M. Ohtsu, E. Fujimoto and N. Kinoshita for technical assistance, M. Takahashi (Nagoya University) for discussion and comments and Y. Nishi for manuscript preparation. This work was supported by special grants-in-aid from the Ministry of Education, Science, Technology, Sports and Culture of Japan; the Haraguchi Memorial Foundation; the Yamanouchi Foundation for Research on Metabolic Disorders; the Takeda Science Foundation; the Kato Memorial Foundation and the Uehara Memorial Foundation.",
year = "2005",
month = jul,
day = "25",
doi = "10.1038/nn1485",
language = "English",
volume = "8",
pages = "855--857",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "7",
}