Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells

Yoshikane Yamauchi, Yotaro Izumi, Keisuke Asakura, Toshinori Fukutomi, Akihiko Serizawa, Kenji Kawai, Masatoshi Wakui, Makoto Suematsu, Hiroaki Nomori

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2. μM) and/or valproic acid (5. mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.

Original languageEnglish
Pages (from-to)328-332
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume410
Issue number2
DOIs
Publication statusPublished - 2011 Jul 1

Keywords

  • Autophagy
  • Cell invasion
  • Lovastatin
  • Mesothelioma
  • Valproic acid

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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