Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells

Yoshikane Yamauchi; Yotaro Izumi; Keisuke Asakura; Toshinori Fukutomi; Akihiko Serizawa; Kenji Kawai; Masatoshi Wakui; Makoto Suematsu; Hiroaki Nomori

doi:10.1016/j.bbrc.2011.05.149

Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells

Yoshikane Yamauchi, Yotaro Izumi, Keisuke Asakura, Toshinori Fukutomi, Akihiko Serizawa, Kenji Kawai, Masatoshi Wakui, Makoto Suematsu, Hiroaki Nomori

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2. μM) and/or valproic acid (5. mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.

Original language	English
Pages (from-to)	328-332
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	410
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2011.05.149
Publication status	Published - 2011 Jul 1

Keywords

Autophagy
Cell invasion
Lovastatin
Mesothelioma
Valproic acid

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2011.05.149

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title = "Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells",

abstract = "Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2. μM) and/or valproic acid (5. mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.",

keywords = "Autophagy, Cell invasion, Lovastatin, Mesothelioma, Valproic acid",

author = "Yoshikane Yamauchi and Yotaro Izumi and Keisuke Asakura and Toshinori Fukutomi and Akihiko Serizawa and Kenji Kawai and Masatoshi Wakui and Makoto Suematsu and Hiroaki Nomori",

note = "Funding Information: We thank Kei Tsujioka, Division of General Thoracic Surgery, for excellent technical assistance. This work was supported in part by grant in aid from the Ministry of Education, Culture, Sports, Science, and Technology-Japan to KA (No. 19790981 ), in part by Global COE Program for Metabolomics Systems Biology from the Ministry of Education, Culture, Sports, Science and Technology to MS, and in part by School of Medicine, Keio University fund for the promotion of science to MW and YI.",

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language = "English",

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pages = "328--332",

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T1 - Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells

AU - Yamauchi, Yoshikane

AU - Izumi, Yotaro

AU - Asakura, Keisuke

AU - Fukutomi, Toshinori

AU - Serizawa, Akihiko

AU - Kawai, Kenji

AU - Wakui, Masatoshi

AU - Suematsu, Makoto

AU - Nomori, Hiroaki

N1 - Funding Information: We thank Kei Tsujioka, Division of General Thoracic Surgery, for excellent technical assistance. This work was supported in part by grant in aid from the Ministry of Education, Culture, Sports, Science, and Technology-Japan to KA (No. 19790981 ), in part by Global COE Program for Metabolomics Systems Biology from the Ministry of Education, Culture, Sports, Science and Technology to MS, and in part by School of Medicine, Keio University fund for the promotion of science to MW and YI.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2. μM) and/or valproic acid (5. mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.

AB - Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2. μM) and/or valproic acid (5. mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.

KW - Autophagy

KW - Cell invasion

KW - Lovastatin

KW - Mesothelioma

KW - Valproic acid

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Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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