Low dose resveratrol ameliorates mitochondrial respiratory dysfunction and enhances cellular reprogramming

Yuki Mizuguchi, Hideyuki Hatakeyama, Kou Sueoka, Mamoru Tanaka, Yu ichi Goto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Mitochondrial disease is associated with a wide variety of clinical presentations, even among patients carrying heteroplasmic mitochondrial DNA (mtDNA) mutations, probably because of variations in mutant mtDNA proportions at the tissue and organ levels. Although several case reports and clinical trials have assessed the effectiveness of various types of drugs and supplements for the treatment of mitochondrial diseases, there are currently no cures for these conditions. In this study, we demonstrated for the first time that low dose resveratrol (RSV) ameliorated mitochondrial respiratory dysfunction in patient-derived fibroblasts carrying homoplasmic mtDNA mutations. Furthermore, low dose RSV also facilitated efficient cellular reprogramming of the patient-derived fibroblasts into induced pluripotent stem cells, partly due to improved cellular viability. Our results highlight the potential of RSV as a new therapeutic drug candidate for the treatment of mitochondrial diseases.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalMitochondrion
Volume34
DOIs
Publication statusPublished - 2017 May 1

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Keywords

  • Mitochondrial disease
  • Mitochondrial respiratory dysfunction
  • Patient-derived induced pluripotent stem cells (iPSCs)
  • Resveratrol

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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