Low-intensity light induces vasorelaxation: a study for possible mechanism

Yuji M D Morimoto, Hirotaka M D Matsuo, Tsunenori Arai, Makoto Kikuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

To investigate the mechanism of light induced vasorelaxation, vascular tension change in normal buffer solution was compared with that in the buffer containing either the following drug: (1) guanylate cyclase inhibitor; (2) nitric oxide synthetase inhibitors and the optical isomers; and (3) vasodilating agent. The vasorelaxation caused by ultraviolet light irradiation was independent of the presence of an intact endothelium. It was inhibited by methyleneblue, but not influenced by either L-NMMA or D-NMMA. On the other hand, this vasorelaxation was enhanced by the agents containing nitro group (L-NAME, D-NAME) or sodium nitrite. These results show that the light activates guanylate cyclase, which results in the vasorelaxation. This activation was reinforced by the agents containing nitro group. We conclude that primary photochemical product, which is probably nitric oxide originated from photodissociation of nitro groups, may produce the vasorelaxation. The preliminary investigation suggests that ultraviolet irradiation may be benefit in the treatment for vasospasm.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsSteven L. Jacques
Pages126-129
Number of pages4
Volume2681
Publication statusPublished - 1996
Externally publishedYes
EventLaser-Tissue Interaction VII - San Jose, CA, USA
Duration: 1996 Jan 291996 Feb 1

Other

OtherLaser-Tissue Interaction VII
CitySan Jose, CA, USA
Period96/1/2996/2/1

Fingerprint

Nitric oxide
Irradiation
Photodissociation
Isomers
Chemical activation
Sodium
Vasodilation
Ultraviolet Rays

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Morimoto, Y. M. D., Matsuo, H. M. D., Arai, T., & Kikuchi, M. (1996). Low-intensity light induces vasorelaxation: a study for possible mechanism. In S. L. Jacques (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2681, pp. 126-129)

Low-intensity light induces vasorelaxation : a study for possible mechanism. / Morimoto, Yuji M D; Matsuo, Hirotaka M D; Arai, Tsunenori; Kikuchi, Makoto.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Steven L. Jacques. Vol. 2681 1996. p. 126-129.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Morimoto, YMD, Matsuo, HMD, Arai, T & Kikuchi, M 1996, Low-intensity light induces vasorelaxation: a study for possible mechanism. in SL Jacques (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2681, pp. 126-129, Laser-Tissue Interaction VII, San Jose, CA, USA, 96/1/29.
Morimoto YMD, Matsuo HMD, Arai T, Kikuchi M. Low-intensity light induces vasorelaxation: a study for possible mechanism. In Jacques SL, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2681. 1996. p. 126-129
Morimoto, Yuji M D ; Matsuo, Hirotaka M D ; Arai, Tsunenori ; Kikuchi, Makoto. / Low-intensity light induces vasorelaxation : a study for possible mechanism. Proceedings of SPIE - The International Society for Optical Engineering. editor / Steven L. Jacques. Vol. 2681 1996. pp. 126-129
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