Abstract
To investigate the mechanism of light induced vasorelaxation, vascular tension change in normal buffer solution was compared with that in the buffer containing either the following drug: (1) guanylate cyclase inhibitor; (2) nitric oxide synthetase inhibitors and the optical isomers; and (3) vasodilating agent. The vasorelaxation caused by ultraviolet light irradiation was independent of the presence of an intact endothelium. It was inhibited by methyleneblue, but not influenced by either L-NMMA or D-NMMA. On the other hand, this vasorelaxation was enhanced by the agents containing nitro group (L-NAME, D-NAME) or sodium nitrite. These results show that the light activates guanylate cyclase, which results in the vasorelaxation. This activation was reinforced by the agents containing nitro group. We conclude that primary photochemical product, which is probably nitric oxide originated from photodissociation of nitro groups, may produce the vasorelaxation. The preliminary investigation suggests that ultraviolet irradiation may be benefit in the treatment for vasospasm.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | Steven L. Jacques |
| Pages | 126-129 |
| Number of pages | 4 |
| Volume | 2681 |
| Publication status | Published - 1996 |
| Externally published | Yes |
| Event | Laser-Tissue Interaction VII - San Jose, CA, USA Duration: 1996 Jan 29 → 1996 Feb 1 |
Other
| Other | Laser-Tissue Interaction VII |
|---|---|
| City | San Jose, CA, USA |
| Period | 96/1/29 → 96/2/1 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Low-intensity light induces vasorelaxation : a study for possible mechanism. / Morimoto, Yuji M D; Matsuo, Hirotaka M D; Arai, Tsunenori; Kikuchi, Makoto.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / Steven L. Jacques. Vol. 2681 1996. p. 126-129.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Low-intensity light induces vasorelaxation
T2 - a study for possible mechanism
AU - Morimoto, Yuji M D
AU - Matsuo, Hirotaka M D
AU - Arai, Tsunenori
AU - Kikuchi, Makoto
PY - 1996
Y1 - 1996
N2 - To investigate the mechanism of light induced vasorelaxation, vascular tension change in normal buffer solution was compared with that in the buffer containing either the following drug: (1) guanylate cyclase inhibitor; (2) nitric oxide synthetase inhibitors and the optical isomers; and (3) vasodilating agent. The vasorelaxation caused by ultraviolet light irradiation was independent of the presence of an intact endothelium. It was inhibited by methyleneblue, but not influenced by either L-NMMA or D-NMMA. On the other hand, this vasorelaxation was enhanced by the agents containing nitro group (L-NAME, D-NAME) or sodium nitrite. These results show that the light activates guanylate cyclase, which results in the vasorelaxation. This activation was reinforced by the agents containing nitro group. We conclude that primary photochemical product, which is probably nitric oxide originated from photodissociation of nitro groups, may produce the vasorelaxation. The preliminary investigation suggests that ultraviolet irradiation may be benefit in the treatment for vasospasm.
AB - To investigate the mechanism of light induced vasorelaxation, vascular tension change in normal buffer solution was compared with that in the buffer containing either the following drug: (1) guanylate cyclase inhibitor; (2) nitric oxide synthetase inhibitors and the optical isomers; and (3) vasodilating agent. The vasorelaxation caused by ultraviolet light irradiation was independent of the presence of an intact endothelium. It was inhibited by methyleneblue, but not influenced by either L-NMMA or D-NMMA. On the other hand, this vasorelaxation was enhanced by the agents containing nitro group (L-NAME, D-NAME) or sodium nitrite. These results show that the light activates guanylate cyclase, which results in the vasorelaxation. This activation was reinforced by the agents containing nitro group. We conclude that primary photochemical product, which is probably nitric oxide originated from photodissociation of nitro groups, may produce the vasorelaxation. The preliminary investigation suggests that ultraviolet irradiation may be benefit in the treatment for vasospasm.
UR - http://www.scopus.com/inward/record.url?scp=0029748451&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029748451&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0029748451
SN - 0819420557
SN - 9780819420558
VL - 2681
SP - 126
EP - 129
BT - Proceedings of SPIE - The International Society for Optical Engineering
A2 - Jacques, Steven L.
ER -