Low prevalence of activated protein C resistance and coagulation factor V Arg506 to Gln mutation among Japanese patients with various forms of thrombosis, and normal individuals

Takeru Zama, Mitsuru Murata, Fumiko Ono, Kiyoaki Watanabe, Reiko Watanabe, Takanori Moriki, Kenji Yokoyama, Michihide Tokuhira, Yasuo Ikeda

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26 Citations (Scopus)


Resistance to activated protein C (APC), recently reported to be the most prevalent inherited cause of thrombosis among Caucasians, is associated with a single point mutation in the coagulation factor V gene. We investigated the prevalence of APC resistance and the factor V gene mutation (R506Q) in 34 consecutive Japanese patients with venous thrombosis or pulmonary thromboembolisin and 63 control subjects. Three of the 33 patients examined (9%) had an APC ratio below the 5th percentile of control values (2.27), but all were above 2.0. The factor V mutation (R506Q) was not detected in the 29 patients studied, including the 3 patients whose APC ratios were below 2.27, or in 53 controls. In a tissue factor-based factor V assay to detect APC resistance recently described by Le et al. (Blood 1995;85:1704-1711), all patients studied were found to be normal including the three with a low APC ratio. We conclude that APC resistance and factor V gene mutation are less prevalent in Japan than in several European countries.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalInternational Journal of Hematology
Issue number1
Publication statusPublished - 1996 Dec



  • Activated protein C resistance
  • Coagulation factor V
  • Mutation
  • Thrombophilial Venous thrombosis

ASJC Scopus subject areas

  • Hematology

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