Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis

Shunsuke Yamamoto, Kenji Watabe, Shusaku Tsutsui, Shinichi Kiso, Toshimitsu Hamasaki, Motohiko Kato, Yoshihiro Kamada, Yuichi Yoshida, Shinji Kihara, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Norio Hayashi, Yuji Matsuzawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear. Aims: The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis. Methods: We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus' suckers. Results: A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95% CI 0.93-0.99), smoking (OR 0.50; 95% CI 0.30-0.80), higher blood pressure (OR 1.02; 95% CI 1.01-1.03), and duodenitis (OR 1.8; 95% CI 1.00-3.09) were significantly associated with endoscopic erosive gastritis. Conclusions: Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.

Original languageEnglish
Pages (from-to)2354-2360
Number of pages7
JournalDigestive Diseases and Sciences
Volume56
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1
Externally publishedYes

Fingerprint

Adiponectin
Gastritis
Serum
Body Mass Index
Habits
Obesity
Smoking
Duodenitis
Octopodiformes
Age Factors
Dental Caries
Medical Records
Triglycerides
Anti-Inflammatory Agents
Logistic Models
Fats
Cholesterol
Regression Analysis
Alcohols
Insulin

Keywords

  • Adiponectin
  • Erosive gastritis
  • Health check-up examination
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Yamamoto, S., Watabe, K., Tsutsui, S., Kiso, S., Hamasaki, T., Kato, M., ... Matsuzawa, Y. (2011). Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis. Digestive Diseases and Sciences, 56(8), 2354-2360. https://doi.org/10.1007/s10620-011-1681-3

Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis. / Yamamoto, Shunsuke; Watabe, Kenji; Tsutsui, Shusaku; Kiso, Shinichi; Hamasaki, Toshimitsu; Kato, Motohiko; Kamada, Yoshihiro; Yoshida, Yuichi; Kihara, Shinji; Umeda, Miyuki; Furubayashi, Aiko; Kinoshita, Kazuo; Kishida, Osamu; Fujimoto, Takashi; Yamada, Akira; Tsukamoto, Yoshifumi; Hayashi, Norio; Matsuzawa, Yuji.

In: Digestive Diseases and Sciences, Vol. 56, No. 8, 01.08.2011, p. 2354-2360.

Research output: Contribution to journalArticle

Yamamoto, S, Watabe, K, Tsutsui, S, Kiso, S, Hamasaki, T, Kato, M, Kamada, Y, Yoshida, Y, Kihara, S, Umeda, M, Furubayashi, A, Kinoshita, K, Kishida, O, Fujimoto, T, Yamada, A, Tsukamoto, Y, Hayashi, N & Matsuzawa, Y 2011, 'Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis', Digestive Diseases and Sciences, vol. 56, no. 8, pp. 2354-2360. https://doi.org/10.1007/s10620-011-1681-3
Yamamoto, Shunsuke ; Watabe, Kenji ; Tsutsui, Shusaku ; Kiso, Shinichi ; Hamasaki, Toshimitsu ; Kato, Motohiko ; Kamada, Yoshihiro ; Yoshida, Yuichi ; Kihara, Shinji ; Umeda, Miyuki ; Furubayashi, Aiko ; Kinoshita, Kazuo ; Kishida, Osamu ; Fujimoto, Takashi ; Yamada, Akira ; Tsukamoto, Yoshifumi ; Hayashi, Norio ; Matsuzawa, Yuji. / Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis. In: Digestive Diseases and Sciences. 2011 ; Vol. 56, No. 8. pp. 2354-2360.
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abstract = "Background: Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear. Aims: The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis. Methods: We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus' suckers. Results: A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95{\%} CI 0.93-0.99), smoking (OR 0.50; 95{\%} CI 0.30-0.80), higher blood pressure (OR 1.02; 95{\%} CI 1.01-1.03), and duodenitis (OR 1.8; 95{\%} CI 1.00-3.09) were significantly associated with endoscopic erosive gastritis. Conclusions: Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.",
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AU - Yamamoto, Shunsuke

AU - Watabe, Kenji

AU - Tsutsui, Shusaku

AU - Kiso, Shinichi

AU - Hamasaki, Toshimitsu

AU - Kato, Motohiko

AU - Kamada, Yoshihiro

AU - Yoshida, Yuichi

AU - Kihara, Shinji

AU - Umeda, Miyuki

AU - Furubayashi, Aiko

AU - Kinoshita, Kazuo

AU - Kishida, Osamu

AU - Fujimoto, Takashi

AU - Yamada, Akira

AU - Tsukamoto, Yoshifumi

AU - Hayashi, Norio

AU - Matsuzawa, Yuji

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N2 - Background: Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear. Aims: The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis. Methods: We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus' suckers. Results: A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95% CI 0.93-0.99), smoking (OR 0.50; 95% CI 0.30-0.80), higher blood pressure (OR 1.02; 95% CI 1.01-1.03), and duodenitis (OR 1.8; 95% CI 1.00-3.09) were significantly associated with endoscopic erosive gastritis. Conclusions: Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.

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KW - Obesity

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