LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian andJapanese men

Tomonori Okamura, Akira Sekikawa, Tatsuya Sawamura, Takashi Kadowaki, Emma Barinas-Mitchell, Rachel H. Mackey, Aya Kadota, Rhobert W. Evans, Daniel Edmundowicz, Aya Higashiyama, Yasuyuki Nakamura, Robert D. Abbott, Katsuyuki Miura, Akira Fujiyoshi, Yoshiko Fujita, Yoshitaka Murakami, Naomi Miyamatsu, Akemi Kakino, Hiroshi Maegawa, Kiyoshi MurataMinoru Horie, Kenichi Mitsunami, Atsunori Kashiwagi, Lewis H. Kuller, Hirotsugu Ueshima

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC), total LDL particles and usual measurement of oxidized LDL. The association between LAB and intima-media thickness (IMT) of carotid artery was investigated by ultrasound in US and Japan men. Methods: Participants were 297 US Caucasian and 310 Japanese men, aged 40-49 years without past history of cardiovascular disease. Serum LAB levels were measured by ELISAs with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results: Serum LAB levels [median (interquartile range), μg/L] were 1321 (936, 1730) in US Caucasians and 940 (688, 1259) in Japanese. For Caucasian men, average IMT was higher in higher LAB quartile, which was 0.653, 0.667, 0.688, and 0.702. mm, respectively (p for trend. =. 0.02). Linear regression analysis showed serum LAB was significantly associated with IMT after adjustment for LDLC or total LDL particles in addition to other traditional or novel risk factors for atherosclerosis such as C-reactive protein. However, there was no significant relationship between LAB and IMT in Japanese men. Conclusion: Serum LAB, a new candidate biomarker for residual risk, was associated with an increased carotid IMT in US Caucasian men independently of various risk factors; however, ethnic difference should be clarified in the future.

Original languageEnglish
Pages (from-to)240-245
Number of pages6
JournalAtherosclerosis
Volume229
Issue number1
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Carotid intima-media thickness
  • LOX-1 ligand containing ApoB
  • Lectin-like oxidized LDL receptor 1
  • Population
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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