TY - JOUR
T1 - LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian andJapanese men
AU - Okamura, Tomonori
AU - Sekikawa, Akira
AU - Sawamura, Tatsuya
AU - Kadowaki, Takashi
AU - Barinas-Mitchell, Emma
AU - Mackey, Rachel H.
AU - Kadota, Aya
AU - Evans, Rhobert W.
AU - Edmundowicz, Daniel
AU - Higashiyama, Aya
AU - Nakamura, Yasuyuki
AU - Abbott, Robert D.
AU - Miura, Katsuyuki
AU - Fujiyoshi, Akira
AU - Fujita, Yoshiko
AU - Murakami, Yoshitaka
AU - Miyamatsu, Naomi
AU - Kakino, Akemi
AU - Maegawa, Hiroshi
AU - Murata, Kiyoshi
AU - Horie, Minoru
AU - Mitsunami, Kenichi
AU - Kashiwagi, Atsunori
AU - Kuller, Lewis H.
AU - Ueshima, Hirotsugu
N1 - Funding Information:
This research was supported by grants R01 HL68200 and HL071561 from the National Institutes of Health . This research was supported by a Grant-in-Aid for Scientific Research ( (B):23390178 ) by the Japan Society for the Promotion of Science and a Grant-in-Aid for Scientific Research ( (A):13307016 ) by the Japanese Ministry of Education, Culture, Sports, Science and Technology .
PY - 2013/7
Y1 - 2013/7
N2 - Objective: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC), total LDL particles and usual measurement of oxidized LDL. The association between LAB and intima-media thickness (IMT) of carotid artery was investigated by ultrasound in US and Japan men. Methods: Participants were 297 US Caucasian and 310 Japanese men, aged 40-49 years without past history of cardiovascular disease. Serum LAB levels were measured by ELISAs with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results: Serum LAB levels [median (interquartile range), μg/L] were 1321 (936, 1730) in US Caucasians and 940 (688, 1259) in Japanese. For Caucasian men, average IMT was higher in higher LAB quartile, which was 0.653, 0.667, 0.688, and 0.702. mm, respectively (p for trend. =. 0.02). Linear regression analysis showed serum LAB was significantly associated with IMT after adjustment for LDLC or total LDL particles in addition to other traditional or novel risk factors for atherosclerosis such as C-reactive protein. However, there was no significant relationship between LAB and IMT in Japanese men. Conclusion: Serum LAB, a new candidate biomarker for residual risk, was associated with an increased carotid IMT in US Caucasian men independently of various risk factors; however, ethnic difference should be clarified in the future.
AB - Objective: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC), total LDL particles and usual measurement of oxidized LDL. The association between LAB and intima-media thickness (IMT) of carotid artery was investigated by ultrasound in US and Japan men. Methods: Participants were 297 US Caucasian and 310 Japanese men, aged 40-49 years without past history of cardiovascular disease. Serum LAB levels were measured by ELISAs with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results: Serum LAB levels [median (interquartile range), μg/L] were 1321 (936, 1730) in US Caucasians and 940 (688, 1259) in Japanese. For Caucasian men, average IMT was higher in higher LAB quartile, which was 0.653, 0.667, 0.688, and 0.702. mm, respectively (p for trend. =. 0.02). Linear regression analysis showed serum LAB was significantly associated with IMT after adjustment for LDLC or total LDL particles in addition to other traditional or novel risk factors for atherosclerosis such as C-reactive protein. However, there was no significant relationship between LAB and IMT in Japanese men. Conclusion: Serum LAB, a new candidate biomarker for residual risk, was associated with an increased carotid IMT in US Caucasian men independently of various risk factors; however, ethnic difference should be clarified in the future.
KW - Carotid intima-media thickness
KW - LOX-1 ligand containing ApoB
KW - Lectin-like oxidized LDL receptor 1
KW - Population
KW - Risk factors
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U2 - 10.1016/j.atherosclerosis.2013.04.023
DO - 10.1016/j.atherosclerosis.2013.04.023
M3 - Article
C2 - 23683938
AN - SCOPUS:84879413406
SN - 0021-9150
VL - 229
SP - 240
EP - 245
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -
