Lupus low disease activity state within 12 months is associated with favourable outcomes in severely active systemic lupus erythematosus

Jun Kikuchi, Hironari Hanaoka, Shuntaro Saito, Tatsuhiro Oshige, Kazuoto Hiramoto, Yuko Kaneko, Tsutomu Takeuchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

OBJECTIVES: To demonstrate the significance of the time to attain lupus low disease activity state (LLDAS) after remission induction therapy in patients with severely active SLE. METHODS: We enrolled 79 patients starting prednisolone ≥0.4 mg/kg/day for active lupus with a BILAG 2004 index of A ≥ 1 or B ≥ 2, or for severe flare based on the Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI). The time to LLDAS attainment was divided into ≤6, 6-12 and >12 months and non-LLDAS; associations between the timing of LLDAS and flares, damage accrual and ≥50% LLDAS attainment were examined. RESULTS: The mean SLEDAI was 17; median starting dose of prednisolone, 0.95 mg/kg/day; and mean observational period, 39.7 months. Six (7.6%) and 41 (51.9%) patients achieved LLDAS within 6 and 12 months. Patients with a shorter time to LLDAS achievement were more likely to spend ≥50% of the time in LLDAS and had a lower cumulative prednisolone dose; no differences were observed in damage accrual. Patients requiring longer than 12 months to achieve LLDAS had a higher prevalence of thrombocytopenia and those with non-LLDAS had lower renal function and a higher starting dose of prednisolone and steroid pulse therapy than those who achieved LLDAS within 12 months. CONCLUSION: Achieving LLDAS within 12 months of induction therapy may be favourable in patients with severely active SLE. The low frequency of LLDAS attainment in high-risk populations highlights the need for a new strategy for SLE treatment.

Original languageEnglish
Pages (from-to)3777-3791
Number of pages15
JournalRheumatology (Oxford, England)
Volume61
Issue number9
DOIs
Publication statusPublished - 2022 Aug 30

Keywords

  • low disease activity
  • lupus low disease activity state
  • outcome measure
  • remission induction therapy
  • systemic lupus erythematosus
  • treatment target

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Lupus low disease activity state within 12 months is associated with favourable outcomes in severely active systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this