Lymph node involvement, recurrence, and prognosis in resected small, peripheral, non-small-cell lung carcinomas

Are these carcinomas candidates for video-assisted lobectomy?

Hisao Asamura, H. Nakayama, H. Kondo, R. Tsuchiya, Y. Shimosato, T. Naruke

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

To determine the clinicopathologic characteristics of peripheral non- small-cell carcinomas, the cases of 337 patients undergoing major pulmonary resection with complete lymphadenectomy were retrospectively reviewed with regard to lymph node involvement, recurrence, and prognosis. All of the tumors were 3.0 cm or less in diameter and were categorized as T1 (318 patients) or T2 (19). Eighty-eight patients (26.1%) had lymph node involvement: 32 (9.5%) at N1 nodes, 55 (16.3%) at N2 nodes, and 1 (0.3%) at N3 nodes. Although the prevalence of lymph node involvement did not differ significantly with tumor histologic type, it was quite low in squamous cell carcinomas 2.0 cm or less in diameter. Of the 56 N2/3 metastases, 14 (25%) occurred in a 'skipping' manner, and all but one had a nonsquamous histologic makeup. Of the 213 patients with a follow-up period of 5 years or more, 59 patients (27.7%) showed cancer recurrence. This occurred at a distant site in 67.8% of the cases. Five-year survival rates based on nodal status were 91.9% (NO), 61.8% (N1), 44.5% (N2), and 0% (N3). Because of the relatively high prevalence of lymph node involvement, complete hilar/mediastinal lymphadenectomy should be routinely done regardless of tumor histologic type and size, as long as patients are at good risk. However, in squamous cell histologic types, mediastinal lymphadenectomy might be dispensable if the tumor is less than 2.0 cm in diameter, or if the hilar node is proved to be tumor-free on pathologic examination of the frozen section during operation. Although video-assisted major pulmonary resection currently has limited application, this new technique may represent a surgical option in resection without complete lymphadenectomy.

Original languageEnglish
Pages (from-to)1125-1134
Number of pages10
JournalJournal of Thoracic and Cardiovascular Surgery
Volume111
Issue number6
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Lymph Nodes
Lymph Node Excision
Carcinoma
Recurrence
Neoplasms
Lung
Small Cell Carcinoma
Frozen Sections
Squamous Cell Carcinoma
Survival Rate
Epithelial Cells
Neoplasm Metastasis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Lymph node involvement, recurrence, and prognosis in resected small, peripheral, non-small-cell lung carcinomas : Are these carcinomas candidates for video-assisted lobectomy? / Asamura, Hisao; Nakayama, H.; Kondo, H.; Tsuchiya, R.; Shimosato, Y.; Naruke, T.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 111, No. 6, 1996, p. 1125-1134.

Research output: Contribution to journalArticle

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abstract = "To determine the clinicopathologic characteristics of peripheral non- small-cell carcinomas, the cases of 337 patients undergoing major pulmonary resection with complete lymphadenectomy were retrospectively reviewed with regard to lymph node involvement, recurrence, and prognosis. All of the tumors were 3.0 cm or less in diameter and were categorized as T1 (318 patients) or T2 (19). Eighty-eight patients (26.1{\%}) had lymph node involvement: 32 (9.5{\%}) at N1 nodes, 55 (16.3{\%}) at N2 nodes, and 1 (0.3{\%}) at N3 nodes. Although the prevalence of lymph node involvement did not differ significantly with tumor histologic type, it was quite low in squamous cell carcinomas 2.0 cm or less in diameter. Of the 56 N2/3 metastases, 14 (25{\%}) occurred in a 'skipping' manner, and all but one had a nonsquamous histologic makeup. Of the 213 patients with a follow-up period of 5 years or more, 59 patients (27.7{\%}) showed cancer recurrence. This occurred at a distant site in 67.8{\%} of the cases. Five-year survival rates based on nodal status were 91.9{\%} (NO), 61.8{\%} (N1), 44.5{\%} (N2), and 0{\%} (N3). Because of the relatively high prevalence of lymph node involvement, complete hilar/mediastinal lymphadenectomy should be routinely done regardless of tumor histologic type and size, as long as patients are at good risk. However, in squamous cell histologic types, mediastinal lymphadenectomy might be dispensable if the tumor is less than 2.0 cm in diameter, or if the hilar node is proved to be tumor-free on pathologic examination of the frozen section during operation. Although video-assisted major pulmonary resection currently has limited application, this new technique may represent a surgical option in resection without complete lymphadenectomy.",
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