Lymphoepithelioma-like hepatocellular carcinoma

A case report and a review of the literature

Masahiro Shinoda, Yoshie Kadota, Hanako Tsujikawa, Yohei Masugi, Osamu Itano, Akihisa Ueno, Kisho Mihara, Taizo Hibi, Yuta Abe, Hiroshi Yagi, Minoru Kitago, Shigeyuki Kawachi, Akihiro Tanimoto, Michiie Sakamoto, Minoru Tanabe, Yuukou Kitagawa

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Abstract

We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.

Original languageEnglish
Article number97
JournalWorld Journal of Surgical Oncology
Volume11
DOIs
Publication statusPublished - 2013 May 4

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Hepatocellular Carcinoma
Bile Duct Neoplasms
Neoplasms
Lymph Nodes
Extrahepatic Bile Ducts
Segmental Mastectomy
Abdominal Aorta
Serology
Hepatitis B virus
Hepacivirus
Adenocarcinoma
Thorax
Tomography
Neoplasm Metastasis
Carcinoma
Liver

Keywords

  • Hepatocellular carcinoma
  • Lymphoepithelioma
  • Lymphoepithelioma-like carcinoma

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

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title = "Lymphoepithelioma-like hepatocellular carcinoma: A case report and a review of the literature",
abstract = "We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.",
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author = "Masahiro Shinoda and Yoshie Kadota and Hanako Tsujikawa and Yohei Masugi and Osamu Itano and Akihisa Ueno and Kisho Mihara and Taizo Hibi and Yuta Abe and Hiroshi Yagi and Minoru Kitago and Shigeyuki Kawachi and Akihiro Tanimoto and Michiie Sakamoto and Minoru Tanabe and Yuukou Kitagawa",
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T1 - Lymphoepithelioma-like hepatocellular carcinoma

T2 - A case report and a review of the literature

AU - Shinoda, Masahiro

AU - Kadota, Yoshie

AU - Tsujikawa, Hanako

AU - Masugi, Yohei

AU - Itano, Osamu

AU - Ueno, Akihisa

AU - Mihara, Kisho

AU - Hibi, Taizo

AU - Abe, Yuta

AU - Yagi, Hiroshi

AU - Kitago, Minoru

AU - Kawachi, Shigeyuki

AU - Tanimoto, Akihiro

AU - Sakamoto, Michiie

AU - Tanabe, Minoru

AU - Kitagawa, Yuukou

PY - 2013/5/4

Y1 - 2013/5/4

N2 - We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.

AB - We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.

KW - Hepatocellular carcinoma

KW - Lymphoepithelioma

KW - Lymphoepithelioma-like carcinoma

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