Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice

Mika Ikebe, Kazuhisa Miyakawa, Kiyoshi Takahashi, Kazuyuki Ohbo, Masataka Nakamura, Kazuo Sugamura, Toshio Suda, Ken Ichi Yamamura, Kimio Tomita

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Abstract

Interleukin-2 (IL-2) receptor γ chain-deficient mice with a truncated mutation showed the absence or severe reduction of natural killer cells, decreased numbers of T- and B-cells, marked hypoplasia of the thymus and peripheral lymphoid tissues, defective formation of lymphoid follicles and germinal centre in the peripheral lymphoid tissues, and the absence of Payer's patches in the intestinal mucosa. In addition, marked splenomegaly with extramedullary haematopoiesis, increased level of IgM and decreased levels of IgG and IgE in serum, severe reduction of conventional B cells (B- 2) in the peripheral lymphoid tissues, the presence of IgM-producing CD5+ B cells (B-1) and their differentiation into plasma cells and Motto cells in the spleen, and increased production and differentiation of macrophages in various tissues were found in the mutant mice. However, the development of both marginal metallophilic macrophage populations in the spleen and of their related macrophages in the other tissues of the mutant mice was severely impaired. All these abnormalities seem to be induced by the loss-of-function of the IL-2 receptor γ chain. From 8 weeks of age on, inflammatory changes occurred in the intestines, mesenteric lymph nodes, lungs, liver, and kidneys of the mutant mice. Besides the absence of Hassall's corpuscles, thymic cysts were frequently observed in the mutant mice. These pathological abnormalities suggest that the γ chain is implicated not only in lymphoid and haematepoietic development but also in thymic epithelial cell ontogeny.

Original languageEnglish
Pages (from-to)133-148
Number of pages16
JournalInternational Journal of Experimental Pathology
Volume78
Issue number3
Publication statusPublished - 1997

Fingerprint

Lymphoproliferative Disorders
Interleukin-2 Receptors
Lymphoid Tissue
B-Lymphocytes
Macrophages
Immunoglobulin M
Spleen
Extramedullary Hematopoiesis
Mediastinal Cyst
Germinal Center
Splenomegaly
Intestinal Mucosa
Plasma Cells
Natural Killer Cells
Thymus Gland
Immunoglobulin E
Intestines
Cell Count
Immunoglobulin G
Lymph Nodes

Keywords

  • Immunohistochemistry
  • Interleukin 2 receptor
  • Intestinal bowel disease
  • Lymphoid hypoplasia
  • Lymphoproliferative disorder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ikebe, M., Miyakawa, K., Takahashi, K., Ohbo, K., Nakamura, M., Sugamura, K., ... Tomita, K. (1997). Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice. International Journal of Experimental Pathology, 78(3), 133-148.

Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice. / Ikebe, Mika; Miyakawa, Kazuhisa; Takahashi, Kiyoshi; Ohbo, Kazuyuki; Nakamura, Masataka; Sugamura, Kazuo; Suda, Toshio; Yamamura, Ken Ichi; Tomita, Kimio.

In: International Journal of Experimental Pathology, Vol. 78, No. 3, 1997, p. 133-148.

Research output: Contribution to journalArticle

Ikebe, M, Miyakawa, K, Takahashi, K, Ohbo, K, Nakamura, M, Sugamura, K, Suda, T, Yamamura, KI & Tomita, K 1997, 'Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice', International Journal of Experimental Pathology, vol. 78, no. 3, pp. 133-148.
Ikebe, Mika ; Miyakawa, Kazuhisa ; Takahashi, Kiyoshi ; Ohbo, Kazuyuki ; Nakamura, Masataka ; Sugamura, Kazuo ; Suda, Toshio ; Yamamura, Ken Ichi ; Tomita, Kimio. / Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice. In: International Journal of Experimental Pathology. 1997 ; Vol. 78, No. 3. pp. 133-148.
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