Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis

Hideto Kameda; Ayumi Okuyama; Jun Ichi Tamaru; Shinji Itoyama; Atsushi Iizuka; Tsutomu Takeuchi

doi:10.1007/s10067-006-0480-2

Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis

Hideto Kameda, Ayumi Okuyama, Jun Ichi Tamaru, Shinji Itoyama, Atsushi Iizuka, Tsutomu Takeuchi

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

We report on a patient of rheumatoid arthritis (RA) who sequentially developed an axillary mass and a fatal interstitial pneumonia during a 2-year course of methotrexate (MTX) therapy. Autopsy revealed a systemic lymph node involvement and the diagnosis of Epstein-Barr virus (EBV)-related lymphoproliferative disease (LPD) with the features of lymphomatoid granulomatosis was made. The lung tissue specimens revealed a typical diffuse alveolar damage (DAD), and small nodules consisting of atypical B lymphocytes showing positive staining for EBV were sparsely recognized only in basal lungs. This is the first report of a RA patient receiving MTX therapy sequentially developing MTX-associated lymphomatoid granulomatosis and DAD.

Original language	English
Pages (from-to)	1585-1589
Number of pages	5
Journal	Clinical Rheumatology
Volume	26
Issue number	9
DOIs	https://doi.org/10.1007/s10067-006-0480-2
Publication status	Published - 2007 Sept 1
Externally published	Yes

Keywords

Diffuse alveolar damage
Epstein-Barrvirus
Lymphomatoid granulomatosis
Methotrexate
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology

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10.1007/s10067-006-0480-2

Cite this

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title = "Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis",

abstract = "We report on a patient of rheumatoid arthritis (RA) who sequentially developed an axillary mass and a fatal interstitial pneumonia during a 2-year course of methotrexate (MTX) therapy. Autopsy revealed a systemic lymph node involvement and the diagnosis of Epstein-Barr virus (EBV)-related lymphoproliferative disease (LPD) with the features of lymphomatoid granulomatosis was made. The lung tissue specimens revealed a typical diffuse alveolar damage (DAD), and small nodules consisting of atypical B lymphocytes showing positive staining for EBV were sparsely recognized only in basal lungs. This is the first report of a RA patient receiving MTX therapy sequentially developing MTX-associated lymphomatoid granulomatosis and DAD.",

keywords = "Diffuse alveolar damage, Epstein-Barrvirus, Lymphomatoid granulomatosis, Methotrexate, Rheumatoid arthritis",

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AU - Kameda, Hideto

AU - Okuyama, Ayumi

AU - Tamaru, Jun Ichi

AU - Itoyama, Shinji

AU - Iizuka, Atsushi

AU - Takeuchi, Tsutomu

PY - 2007/9/1

Y1 - 2007/9/1

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KW - Diffuse alveolar damage

KW - Epstein-Barrvirus

KW - Lymphomatoid granulomatosis

KW - Methotrexate

KW - Rheumatoid arthritis

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Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis

Abstract

Keywords

ASJC Scopus subject areas

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