Lysophosphatidic acid as a novel cell survival/apoptotic factor

Xiaoqin Ye, Isao Ishii, Marcy A. Kingsbury, Jerold Chun

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1585
Issue number2-3
DOIs
Publication statusPublished - 2002 Dec 30
Externally publishedYes

Fingerprint

Cell Survival
Pertussis Toxin
Apoptosis
Myeloid Progenitor Cells
1-Phosphatidylinositol 4-Kinase
PC12 Cells
Schwann Cells
Pathologic Processes
Caspases
G-Protein-Coupled Receptors
lysophosphatidic acid
Lipids
Neurons
Proteins

Keywords

  • Apoptosis
  • LPA
  • LPA receptor
  • Schwann cell
  • Survival

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Biophysics

Cite this

Lysophosphatidic acid as a novel cell survival/apoptotic factor. / Ye, Xiaoqin; Ishii, Isao; Kingsbury, Marcy A.; Chun, Jerold.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1585, No. 2-3, 30.12.2002, p. 108-113.

Research output: Contribution to journalArticle

Ye, Xiaoqin ; Ishii, Isao ; Kingsbury, Marcy A. ; Chun, Jerold. / Lysophosphatidic acid as a novel cell survival/apoptotic factor. In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2002 ; Vol. 1585, No. 2-3. pp. 108-113.
@article{266a851f4c4941428941694c92bd2331,
title = "Lysophosphatidic acid as a novel cell survival/apoptotic factor",
abstract = "Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.",
keywords = "Apoptosis, LPA, LPA receptor, Schwann cell, Survival",
author = "Xiaoqin Ye and Isao Ishii and Kingsbury, {Marcy A.} and Jerold Chun",
year = "2002",
month = "12",
day = "30",
doi = "10.1016/S1388-1981(02)00330-X",
language = "English",
volume = "1585",
pages = "108--113",
journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",
issn = "1388-1981",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Lysophosphatidic acid as a novel cell survival/apoptotic factor

AU - Ye, Xiaoqin

AU - Ishii, Isao

AU - Kingsbury, Marcy A.

AU - Chun, Jerold

PY - 2002/12/30

Y1 - 2002/12/30

N2 - Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.

AB - Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.

KW - Apoptosis

KW - LPA

KW - LPA receptor

KW - Schwann cell

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=0037203315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037203315&partnerID=8YFLogxK

U2 - 10.1016/S1388-1981(02)00330-X

DO - 10.1016/S1388-1981(02)00330-X

M3 - Article

C2 - 12531543

AN - SCOPUS:0037203315

VL - 1585

SP - 108

EP - 113

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

SN - 1388-1981

IS - 2-3

ER -