Lysophosphatidic acid as a novel cell survival/apoptotic factor

Xiaoqin Ye, Isao Ishii, Marcy A. Kingsbury, Jerold Chun

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1585
Issue number2-3
DOIs
Publication statusPublished - 2002 Dec 30

Keywords

  • Apoptosis
  • LPA
  • LPA receptor
  • Schwann cell
  • Survival

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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