Lysophosphatidic acid receptors

James J A Contos, Isao Ishii, Jerold Chun

Research output: Contribution to journalArticle

341 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, Ip(A1)/vzg-1/Edg2, Ip(A2)/Edg4, and Ip(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

Original languageEnglish
Pages (from-to)1188-1196
Number of pages9
JournalMolecular Pharmacology
Volume58
Issue number6
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Lysophosphatidic Acid Receptors
Neurogenesis
varespladib methyl
Wound Healing
Phospholipids
Gene Expression
Genes
lysophosphatidic acid
Neoplasms

ASJC Scopus subject areas

  • Pharmacology

Cite this

Contos, J. J. A., Ishii, I., & Chun, J. (2000). Lysophosphatidic acid receptors. Molecular Pharmacology, 58(6), 1188-1196.

Lysophosphatidic acid receptors. / Contos, James J A; Ishii, Isao; Chun, Jerold.

In: Molecular Pharmacology, Vol. 58, No. 6, 2000, p. 1188-1196.

Research output: Contribution to journalArticle

Contos, JJA, Ishii, I & Chun, J 2000, 'Lysophosphatidic acid receptors', Molecular Pharmacology, vol. 58, no. 6, pp. 1188-1196.
Contos JJA, Ishii I, Chun J. Lysophosphatidic acid receptors. Molecular Pharmacology. 2000;58(6):1188-1196.
Contos, James J A ; Ishii, Isao ; Chun, Jerold. / Lysophosphatidic acid receptors. In: Molecular Pharmacology. 2000 ; Vol. 58, No. 6. pp. 1188-1196.
@article{c7a186b6883847cc8c5f585b7c563088,
title = "Lysophosphatidic acid receptors",
abstract = "Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, Ip(A1)/vzg-1/Edg2, Ip(A2)/Edg4, and Ip(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.",
author = "Contos, {James J A} and Isao Ishii and Jerold Chun",
year = "2000",
language = "English",
volume = "58",
pages = "1188--1196",
journal = "Molecular Pharmacology",
issn = "0026-895X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "6",

}

TY - JOUR

T1 - Lysophosphatidic acid receptors

AU - Contos, James J A

AU - Ishii, Isao

AU - Chun, Jerold

PY - 2000

Y1 - 2000

N2 - Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, Ip(A1)/vzg-1/Edg2, Ip(A2)/Edg4, and Ip(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

AB - Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, Ip(A1)/vzg-1/Edg2, Ip(A2)/Edg4, and Ip(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

UR - http://www.scopus.com/inward/record.url?scp=0033669622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033669622&partnerID=8YFLogxK

M3 - Article

C2 - 11093753

AN - SCOPUS:0033669622

VL - 58

SP - 1188

EP - 1196

JO - Molecular Pharmacology

JF - Molecular Pharmacology

SN - 0026-895X

IS - 6

ER -