Lysophosphatidic acid receptors

James J.A. Contos, Isao Ishii, Jerold Chun

Research output: Contribution to journalShort survey

345 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, Ip(A1)/vzg-1/Edg2, Ip(A2)/Edg4, and Ip(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

Original languageEnglish
Pages (from-to)1188-1196
Number of pages9
JournalMolecular Pharmacology
Volume58
Issue number6
DOIs
Publication statusPublished - 2000 Jan 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Contos, J. J. A., Ishii, I., & Chun, J. (2000). Lysophosphatidic acid receptors. Molecular Pharmacology, 58(6), 1188-1196. https://doi.org/10.1124/mol.58.6.1188