Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1

Yoshino Yonezu, Shogo Tanabe, Hidemi Misawa, Rieko Muramatsu

Research output: Contribution to journalArticlepeer-review


Lysophosphatidic acid (LPA) is a bioactive compound known to regulate various vascular functions. However, despite the fact that many vascular functions are regulated by peri-vascular cells such as pericytes, the effect of LPA on brain pericytes has not been fully evaluated. Thus, we designed this study to evaluate the effects of LPA on brain pericytes. These experiments revealed that while LPA receptors (LPARs) are expressed in cultured pericytes from mouse brains, LPA treatment does not influence the proliferation of these cells but does have a profound impact on their migration, which is regulated via the expression of LPAR1. LPAR1 expression was also detected in human pericyte culture and LPA treatment of these cells also induced migration. Taken together these findings imply that LPA-LPAR1 signaling is one of the key mechanisms modulating pericyte migration, which may help to control vascular function during development and repair processes.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalBiochemical and Biophysical Research Communications
Publication statusPublished - 2022 Aug 27


  • AM095
  • Autotaxin
  • Brain
  • Human
  • Mouse
  • Repair

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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