Lysophospholipid receptors: Signaling and biology

Isao Ishii, Nobuyuki Fukushima, Xiaoqin Ye, Jerold Chun

Research output: Contribution to journalArticle

575 Citations (Scopus)

Abstract

Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions influence many biological processes that include neurogenesis, angiogenesis, wound healing, immunity, and carcinogenesis. In recent years, identification of multiple cognate G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and has identified new functions for LP receptor signaling. Efforts to develop LP receptor subtype-specific agonists/antagonists are in progress and raise expectations for a growing collection of chemical tools and potential therapeutic compounds. The rapidly expanding literature on the LP receptors is herein reviewed.

Original languageEnglish
Pages (from-to)321-354
Number of pages34
JournalAnnual Review of Biochemistry
Volume73
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Lysophospholipid Receptors
Lysophospholipids
Biological Phenomena
Neurogenesis
G-Protein-Coupled Receptors
Morphogenesis
Wound Healing
Immunity
Carcinogenesis
Animals
Adhesion
Membranes
Lipids

Keywords

  • G protein-coupled receptor
  • LPA
  • Lysophosphatidic acid
  • Lysophosphatidylcholine
  • SIP
  • Sphingosine 1-phosphate
  • Sphingosylphosphorylcholine

ASJC Scopus subject areas

  • Biochemistry

Cite this

Lysophospholipid receptors : Signaling and biology. / Ishii, Isao; Fukushima, Nobuyuki; Ye, Xiaoqin; Chun, Jerold.

In: Annual Review of Biochemistry, Vol. 73, 2004, p. 321-354.

Research output: Contribution to journalArticle

Ishii, Isao ; Fukushima, Nobuyuki ; Ye, Xiaoqin ; Chun, Jerold. / Lysophospholipid receptors : Signaling and biology. In: Annual Review of Biochemistry. 2004 ; Vol. 73. pp. 321-354.
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