Abstract
Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions influence many biological processes that include neurogenesis, angiogenesis, wound healing, immunity, and carcinogenesis. In recent years, identification of multiple cognate G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and has identified new functions for LP receptor signaling. Efforts to develop LP receptor subtype-specific agonists/antagonists are in progress and raise expectations for a growing collection of chemical tools and potential therapeutic compounds. The rapidly expanding literature on the LP receptors is herein reviewed.
| Original language | English |
|---|---|
| Pages (from-to) | 321-354 |
| Number of pages | 34 |
| Journal | Annual Review of Biochemistry |
| Volume | 73 |
| DOIs | |
| Publication status | Published - 2004 |
| Externally published | Yes |
Fingerprint
Keywords
- G protein-coupled receptor
- LPA
- Lysophosphatidic acid
- Lysophosphatidylcholine
- SIP
- Sphingosine 1-phosphate
- Sphingosylphosphorylcholine
ASJC Scopus subject areas
- Biochemistry
Cite this
Lysophospholipid receptors : Signaling and biology. / Ishii, Isao; Fukushima, Nobuyuki; Ye, Xiaoqin; Chun, Jerold.
In: Annual Review of Biochemistry, Vol. 73, 2004, p. 321-354.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lysophospholipid receptors
T2 - Signaling and biology
AU - Ishii, Isao
AU - Fukushima, Nobuyuki
AU - Ye, Xiaoqin
AU - Chun, Jerold
PY - 2004
Y1 - 2004
N2 - Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions influence many biological processes that include neurogenesis, angiogenesis, wound healing, immunity, and carcinogenesis. In recent years, identification of multiple cognate G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and has identified new functions for LP receptor signaling. Efforts to develop LP receptor subtype-specific agonists/antagonists are in progress and raise expectations for a growing collection of chemical tools and potential therapeutic compounds. The rapidly expanding literature on the LP receptors is herein reviewed.
AB - Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions influence many biological processes that include neurogenesis, angiogenesis, wound healing, immunity, and carcinogenesis. In recent years, identification of multiple cognate G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and has identified new functions for LP receptor signaling. Efforts to develop LP receptor subtype-specific agonists/antagonists are in progress and raise expectations for a growing collection of chemical tools and potential therapeutic compounds. The rapidly expanding literature on the LP receptors is herein reviewed.
KW - G protein-coupled receptor
KW - LPA
KW - Lysophosphatidic acid
KW - Lysophosphatidylcholine
KW - SIP
KW - Sphingosine 1-phosphate
KW - Sphingosylphosphorylcholine
UR - http://www.scopus.com/inward/record.url?scp=2142851264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2142851264&partnerID=8YFLogxK
U2 - 10.1146/annurev.biochem.73.011303.073731
DO - 10.1146/annurev.biochem.73.011303.073731
M3 - Article
C2 - 15189145
AN - SCOPUS:2142851264
VL - 73
SP - 321
EP - 354
JO - Annual Review of Biochemistry
JF - Annual Review of Biochemistry
SN - 0066-4154
ER -