M-Sec: Emerging secrets of tunneling nanotube formation

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Tunneling nanotubes (TNT) are the latest addition to the array of strategies used for intercellular signaling. TNTs are continuous conduits of the plasma membrane that allow direct physical connection of plasma membranes and cytosol among remote cells. They are important for intercellular communication by mediating exchange of cellular components as well as signal transduction molecules. Despite ample evidence suggesting the pathophysiological importance of TNTs, virtually nothing is known about the molecular basis for their formation. With the lack of specific TNT markers, their study has relied solely on morphological analyses, and the precise identity of TNT and TNTlike structures have been difficult to define. We have now shown that M-Sec is a TNT marker and a central factor for TNT formation. In cooperation with the RalA small GTPase and the exocyst complex, M-Sec can induce the formation of functional TNTs, indicating that the remodeling of the actin cytoskeleton is involved in M-Sec-mediated TNT formation. Discovery of the role of M-Sec will accelerate our understanding of TNTs, both at the molecular and physiological levels.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalCommunicative and Integrative Biology
Volume3
Issue number3
DOIs
Publication statusPublished - 2010 May
Externally publishedYes

Fingerprint

nanotubes
Nanotubes
Trinitrotoluene
plasma membrane
Cell Membrane
cell communication
Monomeric GTP-Binding Proteins
guanosinetriphosphatase
microfilaments
Actin Cytoskeleton
cytosol
Cytosol
signal transduction
Signal Transduction

Keywords

  • Exocyst complex
  • F-actin
  • M-Sec
  • RalA
  • Tunneling nanotube
  • Virus infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

M-Sec : Emerging secrets of tunneling nanotube formation. / Ohno, Hiroshi; Hase, Kouji; Kimura, Shunsuke.

In: Communicative and Integrative Biology, Vol. 3, No. 3, 05.2010, p. 231-233.

Research output: Contribution to journalArticle

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