Macrolide-resistant Mycoplasma pneumoniae: Characteristics of isolates and clinical aspects of community-acquired pneumonia

Miyuki Morozumi, Takashi Takahashi, Kimiko Ubukata

Research output: Contribution to journalArticle

120 Citations (Scopus)


Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.

Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalJournal of Infection and Chemotherapy
Issue number2
Publication statusPublished - 2010 Apr
Externally publishedYes



  • Clinical features
  • Community-acquired pneumonia
  • Macrolide resistance
  • Mechanisms of antimicrobial resistance
  • Mycoplasma pneumoniae
  • Real-time PCR

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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