Macrolide-resistant Mycoplasma pneumoniae

Characteristics of isolates and clinical aspects of community-acquired pneumonia

Miyuki Morozumi, Takashi Takahashi, Kimiko Ubukata

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.

Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalJournal of Infection and Chemotherapy
Volume16
Issue number2
DOIs
Publication statusPublished - 2010 Apr
Externally publishedYes

Fingerprint

Mycoplasma pneumoniae
Macrolides
Pneumonia
Pediatrics
Anti-Bacterial Agents
Community-Acquired Infections
Infection
Respiratory Tract Infections
Japan

Keywords

  • Clinical features
  • Community-acquired pneumonia
  • Macrolide resistance
  • Mechanisms of antimicrobial resistance
  • Mycoplasma pneumoniae
  • Real-time PCR

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Macrolide-resistant Mycoplasma pneumoniae : Characteristics of isolates and clinical aspects of community-acquired pneumonia. / Morozumi, Miyuki; Takahashi, Takashi; Ubukata, Kimiko.

In: Journal of Infection and Chemotherapy, Vol. 16, No. 2, 04.2010, p. 78-86.

Research output: Contribution to journalArticle

@article{843893dad63c41deaf35d30578558ac3,
title = "Macrolide-resistant Mycoplasma pneumoniae: Characteristics of isolates and clinical aspects of community-acquired pneumonia",
abstract = "Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.",
keywords = "Clinical features, Community-acquired pneumonia, Macrolide resistance, Mechanisms of antimicrobial resistance, Mycoplasma pneumoniae, Real-time PCR",
author = "Miyuki Morozumi and Takashi Takahashi and Kimiko Ubukata",
year = "2010",
month = "4",
doi = "10.1007/s10156-009-0021-4",
language = "English",
volume = "16",
pages = "78--86",
journal = "Journal of Infection and Chemotherapy",
issn = "1341-321X",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Macrolide-resistant Mycoplasma pneumoniae

T2 - Characteristics of isolates and clinical aspects of community-acquired pneumonia

AU - Morozumi, Miyuki

AU - Takahashi, Takashi

AU - Ubukata, Kimiko

PY - 2010/4

Y1 - 2010/4

N2 - Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.

AB - Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.

KW - Clinical features

KW - Community-acquired pneumonia

KW - Macrolide resistance

KW - Mechanisms of antimicrobial resistance

KW - Mycoplasma pneumoniae

KW - Real-time PCR

UR - http://www.scopus.com/inward/record.url?scp=77952243582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952243582&partnerID=8YFLogxK

U2 - 10.1007/s10156-009-0021-4

DO - 10.1007/s10156-009-0021-4

M3 - Article

VL - 16

SP - 78

EP - 86

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

SN - 1341-321X

IS - 2

ER -