Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.

Takanori Kanai, Koji Uraushihara, Teruji Totsuka, Akira Okazawa, Toshifumi Hibi, Shigeru Oshima, Tatsuya Miyata, Tetsuya Nakamura, Mamoru Watanabe

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalCurrent drug targets. Inflammation and allergy
Volume2
Issue number2
DOIs
Publication statusPublished - 2003 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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