Macrophage Migration Inhibitory Factor and Stearoyl-CoA Desaturase 1

Potential Prognostic Markers for Soft Tissue Sarcomas Based on Bioinformatics Analyses

Hiro Takahashi, Turrent Robert Nakayama, Shuhei Hayashi, Takeshi Nemoto, Yasuyuki Murase, Koji Nomura, Teruyoshi Takahashi, Kenji Kubo, Shigetaka Marui, Koji Yasuhara, Tetsuro Nakamura, Takuya Sueo, Anna Takahashi, Kaname Tsutsumiuchi, Tsutomu Ohta, Akira Kawai, Shintaro Sugita, Shinjiro Yamamoto, Takeshi Kobayashi, Hiroyuki Honda & 2 others Teruhiko Yoshida, Tadashi Hasegawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The diagnosis and treatment of soft tissue sarcomas (STSs) has been particularly difficult, because STSs are a group of highly heterogeneous tumors in terms of histopathology, histological grade, and primary site. Recent advances in genome technologies have provided an excellent opportunity to determine the complete biological characteristics of neoplastic tissues, resulting in improved diagnosis, treatment selection, and investigation of therapeutic targets. We had previously developed a novel bioinformatics method for marker gene selection and applied this method to gene expression data from STS patients. This previous analysis revealed that the extracted gene combination of macrophage migration inhibitory factor (MIF) and stearoyl-CoA desaturase 1 (SCD1) is an effective diagnostic marker to discriminate between subtypes of STSs with highly different outcomes. In the present study, we hypothesize that the combination of MIF and SCD1 is also a prognostic marker for the overall outcome of STSs. To prove this hypothesis, we first analyzed microarray data from 88 STS patients and their outcomes. Our results show that the survival rates for MIF- and SCD1-positive groups were lower than those for negative groups, and the p values of the log-rank test are 0.0146 and 0.00606, respectively. In addition, survival rates are more significantly different (p = 0.000116) between groups that are double-positive and double-negative for MIF and SCD1. Furthermore, in vitro cell growth inhibition experiments by MIF and SCD1 inhibitors support the hypothesis. These results suggest that the gene set is useful as a prognostic marker associated with tumor progression.

Original languageEnglish
Article numbere78250
JournalPLoS One
Volume8
Issue number10
DOIs
Publication statusPublished - 2013 Oct 22

Fingerprint

Stearoyl-CoA Desaturase
Macrophage Migration-Inhibitory Factors
stearoyl-CoA desaturase
sarcoma
Bioinformatics
Computational Biology
bioinformatics
Sarcoma
Tissue
Genes
Survival Rate
Tumors
survival rate
neoplasms
Cell growth
Microarrays
macrophage migration inhibitory factors
tissues
Neoplasms
Gene expression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Macrophage Migration Inhibitory Factor and Stearoyl-CoA Desaturase 1 : Potential Prognostic Markers for Soft Tissue Sarcomas Based on Bioinformatics Analyses. / Takahashi, Hiro; Nakayama, Turrent Robert; Hayashi, Shuhei; Nemoto, Takeshi; Murase, Yasuyuki; Nomura, Koji; Takahashi, Teruyoshi; Kubo, Kenji; Marui, Shigetaka; Yasuhara, Koji; Nakamura, Tetsuro; Sueo, Takuya; Takahashi, Anna; Tsutsumiuchi, Kaname; Ohta, Tsutomu; Kawai, Akira; Sugita, Shintaro; Yamamoto, Shinjiro; Kobayashi, Takeshi; Honda, Hiroyuki; Yoshida, Teruhiko; Hasegawa, Tadashi.

In: PLoS One, Vol. 8, No. 10, e78250, 22.10.2013.

Research output: Contribution to journalArticle

Takahashi, H, Nakayama, TR, Hayashi, S, Nemoto, T, Murase, Y, Nomura, K, Takahashi, T, Kubo, K, Marui, S, Yasuhara, K, Nakamura, T, Sueo, T, Takahashi, A, Tsutsumiuchi, K, Ohta, T, Kawai, A, Sugita, S, Yamamoto, S, Kobayashi, T, Honda, H, Yoshida, T & Hasegawa, T 2013, 'Macrophage Migration Inhibitory Factor and Stearoyl-CoA Desaturase 1: Potential Prognostic Markers for Soft Tissue Sarcomas Based on Bioinformatics Analyses', PLoS One, vol. 8, no. 10, e78250. https://doi.org/10.1371/journal.pone.0078250
Takahashi, Hiro ; Nakayama, Turrent Robert ; Hayashi, Shuhei ; Nemoto, Takeshi ; Murase, Yasuyuki ; Nomura, Koji ; Takahashi, Teruyoshi ; Kubo, Kenji ; Marui, Shigetaka ; Yasuhara, Koji ; Nakamura, Tetsuro ; Sueo, Takuya ; Takahashi, Anna ; Tsutsumiuchi, Kaname ; Ohta, Tsutomu ; Kawai, Akira ; Sugita, Shintaro ; Yamamoto, Shinjiro ; Kobayashi, Takeshi ; Honda, Hiroyuki ; Yoshida, Teruhiko ; Hasegawa, Tadashi. / Macrophage Migration Inhibitory Factor and Stearoyl-CoA Desaturase 1 : Potential Prognostic Markers for Soft Tissue Sarcomas Based on Bioinformatics Analyses. In: PLoS One. 2013 ; Vol. 8, No. 10.
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AU - Hayashi, Shuhei

AU - Nemoto, Takeshi

AU - Murase, Yasuyuki

AU - Nomura, Koji

AU - Takahashi, Teruyoshi

AU - Kubo, Kenji

AU - Marui, Shigetaka

AU - Yasuhara, Koji

AU - Nakamura, Tetsuro

AU - Sueo, Takuya

AU - Takahashi, Anna

AU - Tsutsumiuchi, Kaname

AU - Ohta, Tsutomu

AU - Kawai, Akira

AU - Sugita, Shintaro

AU - Yamamoto, Shinjiro

AU - Kobayashi, Takeshi

AU - Honda, Hiroyuki

AU - Yoshida, Teruhiko

AU - Hasegawa, Tadashi

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