Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma

Shutaro Hori, Kazuaki Shimada, Yoshinori Ino, Seiji Oguro, Minoru Esaki, Satoshi Nara, Yoji Kishi, Tomoo Kosuge, Yukinori Hattori, Aoi Sukeda, Yuukou Kitagawa, Yae Kanai, Nobuyoshi Hiraoka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

As macroscopic appearance represents tumor microenvironment, it may also reflect the biological and clinicopathological characteristics of a cancer. The aim of the study was to evaluate the clinicopathological significance of the gross appearance of pancreatic ductal adenocarcinoma (PDA). We investigated fresh macroscopic features in 352 cases of PDA and their clinicopathological significance. Three unique gross features were found: a honeycomb-like appearance (diffusely distributed microcysts and interstitial fibrotic thickening), macroscopic necrosis, and a tube/branching structure (apparent small cylindrical or linear structure). A honeycomb-like appearance was present in 24 cases (6.8 %) and significantly associated with low serum CA19-9 level and well-differentiated adenocarcinoma. Macroscopic necrosis was present in 235 cases (66.8 %) and significantly correlated with tumor size, nodal metastasis, nerve plexus invasion, no adjuvant chemotherapy, and distant recurrence. The presence of macroscopic necrosis was significantly associated with shorter disease-specific survival (DSS) and disease-free survival (DFS). The presence of larger areas of necrosis (≥2 mm) was closely associated with shorter survival. A tube/branching structure was found in 179 cases (50.9 %), which was correlated with larger tumor size and no adjuvant chemotherapy and macroscopic necrosis. The presence of a tube/branching structure was significantly associated with shorter DSS and DFS. Multivariate survival analyses showed that the presence of tube/branching structures was an independent negative prognostic factor in patients having PDA. We suggest that the gross appearance of PDA reflects clinicopathological characteristics and may be useful in predicting prognosis.

Original languageEnglish
Pages (from-to)621-634
Number of pages14
JournalVirchows Archiv
Volume469
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Adenocarcinoma
Necrosis
Adjuvant Chemotherapy
Disease-Free Survival
Survival
Neoplasms
Tumor Microenvironment
Survival Analysis
Multivariate Analysis
Neoplasm Metastasis
Recurrence
Serum

Keywords

  • A honeycomb-like appearance
  • A tube/branching structure
  • Macroscopic features
  • Macroscopic necrosis
  • Pancreatic ductal adenocarcinoma
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Hori, S., Shimada, K., Ino, Y., Oguro, S., Esaki, M., Nara, S., ... Hiraoka, N. (2016). Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma. Virchows Archiv, 469(6), 621-634. https://doi.org/10.1007/s00428-016-2026-6

Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma. / Hori, Shutaro; Shimada, Kazuaki; Ino, Yoshinori; Oguro, Seiji; Esaki, Minoru; Nara, Satoshi; Kishi, Yoji; Kosuge, Tomoo; Hattori, Yukinori; Sukeda, Aoi; Kitagawa, Yuukou; Kanai, Yae; Hiraoka, Nobuyoshi.

In: Virchows Archiv, Vol. 469, No. 6, 01.12.2016, p. 621-634.

Research output: Contribution to journalArticle

Hori, S, Shimada, K, Ino, Y, Oguro, S, Esaki, M, Nara, S, Kishi, Y, Kosuge, T, Hattori, Y, Sukeda, A, Kitagawa, Y, Kanai, Y & Hiraoka, N 2016, 'Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma', Virchows Archiv, vol. 469, no. 6, pp. 621-634. https://doi.org/10.1007/s00428-016-2026-6
Hori, Shutaro ; Shimada, Kazuaki ; Ino, Yoshinori ; Oguro, Seiji ; Esaki, Minoru ; Nara, Satoshi ; Kishi, Yoji ; Kosuge, Tomoo ; Hattori, Yukinori ; Sukeda, Aoi ; Kitagawa, Yuukou ; Kanai, Yae ; Hiraoka, Nobuyoshi. / Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma. In: Virchows Archiv. 2016 ; Vol. 469, No. 6. pp. 621-634.
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