Macroscopic portal vein tumor thrombi of liver metastasis from colorectal cancer

Takuichi Oikawa, Tadatoshi Takayama, Shunji Okada, Tomohisa Kamo, Masahiko Sugitani, Michiie Sakamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We present a case of multiple colorectal liver metastases with macroscopic portal vein thrombi. A 55-year-old woman presented to us with rectosigmoid cancer and presented with two liver metastases. The tumor in the posterior sector was associated with invasion of first order branches of the portal vein. We performed low anterior resection, hepatic posterior sectorectomy and partial left anterior sectorectomy. Both the colorectal cancer and liver tumors exhibited histological characteristics of moderately differentiated adenocarcinoma with a substantial amount of mucin production. The liver metastases were associated with prominent tumor thrombi in many branches of the portal vein. Stronger staining for endoglin (CD 105) than for Fas ligand (Fas L) and matrix metalloproteinase (MMP-2) was observed in both the colorectal cancer and metastatic liver tumor cells. Expression of the vascular endothelial growth factor within the tumor cells was seen in both the colorectal cancer as well as the metastatic liver tumor cells. Six months after the operation, she was diagnosed to have multiple, more than about 20 liver metastases, and in 9 months after the operation, the patient died. The colorectal cancer with liver metastases associated with portal vein tumor thrombosis was poor prognosis, found neoplastic microvessel formation.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume16
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Portal Vein
Colorectal Neoplasms
Thrombosis
Neoplasm Metastasis
Liver
Neoplasms
Liver Neoplasms
Fas Ligand Protein
Matrix Metalloproteinase 2
Mucins
Microvessels
Matrix Metalloproteinases
Vascular Endothelial Growth Factor A
Adenocarcinoma
Staining and Labeling

Keywords

  • Colorectal cancer
  • Endoglin
  • Liver metastasis
  • Neoplastic microvessels
  • Tumor thrombi in the portal vein

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Cite this

Macroscopic portal vein tumor thrombi of liver metastasis from colorectal cancer. / Oikawa, Takuichi; Takayama, Tadatoshi; Okada, Shunji; Kamo, Tomohisa; Sugitani, Masahiko; Sakamoto, Michiie.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 16, No. 1, 2009, p. 90-93.

Research output: Contribution to journalArticle

Oikawa, Takuichi ; Takayama, Tadatoshi ; Okada, Shunji ; Kamo, Tomohisa ; Sugitani, Masahiko ; Sakamoto, Michiie. / Macroscopic portal vein tumor thrombi of liver metastasis from colorectal cancer. In: Journal of Hepato-Biliary-Pancreatic Surgery. 2009 ; Vol. 16, No. 1. pp. 90-93.
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