Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Shoichiro Suda, Kiyotake Suenaga

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

Original languageEnglish
Pages (from-to)4126-4128
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number30
DOIs
Publication statusPublished - 2014 Jul 23

Keywords

  • Chymotrypsin inhibitor
  • Depsipeptide
  • Lyngbya
  • Maedamide
  • Marine cyanobacteria

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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