Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Shoichiro Suda, Kiyotake Suenaga

Research output: Contribution to journalArticle

11 Citations (Scopus)


Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

Original languageEnglish
Pages (from-to)4126-4128
Number of pages3
JournalTetrahedron Letters
Issue number30
Publication statusPublished - 2014 Jul 23



  • Chymotrypsin inhibitor
  • Depsipeptide
  • Lyngbya
  • Maedamide
  • Marine cyanobacteria

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this