Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Shoichiro Suda; Kiyotake Suenaga

doi:10.1016/j.tetlet.2014.05.099

Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Shoichiro Suda, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

Original language	English
Pages (from-to)	4126-4128
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2014.05.099
Publication status	Published - 2014 Jul 23

Keywords

Chymotrypsin inhibitor
Depsipeptide
Lyngbya
Maedamide
Marine cyanobacteria

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2014.05.099

Cite this

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title = "Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.",

abstract = "Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.",

keywords = "Chymotrypsin inhibitor, Depsipeptide, Lyngbya, Maedamide, Marine cyanobacteria",

author = "Arihiro Iwasaki and Osamu Ohno and Shinpei Sumimoto and Shoichiro Suda and Kiyotake Suenaga",

note = "Funding Information: This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( 24310160 and 25750386 ) and the MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2009–2013 from the Ministry of Education, Culture, Sports, Science and Technology, Japan. ",

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doi = "10.1016/j.tetlet.2014.05.099",

language = "English",

volume = "55",

pages = "4126--4128",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

AU - Iwasaki, Arihiro

AU - Ohno, Osamu

AU - Sumimoto, Shinpei

AU - Suda, Shoichiro

AU - Suenaga, Kiyotake

N1 - Funding Information: This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( 24310160 and 25750386 ) and the MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2009–2013 from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2014/7/23

Y1 - 2014/7/23

N2 - Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

AB - Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

KW - Chymotrypsin inhibitor

KW - Depsipeptide

KW - Lyngbya

KW - Maedamide

KW - Marine cyanobacteria

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U2 - 10.1016/j.tetlet.2014.05.099

DO - 10.1016/j.tetlet.2014.05.099

M3 - Article

AN - SCOPUS:84904048995

SN - 0040-4039

VL - 55

SP - 4126

EP - 4128

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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