Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Wakana Ohashi; Takafumi Hara; Teruhisa Takagishi; Koji Hase; Toshiyuki Fukada

doi:10.1007/s10620-019-05561-2

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Wakana Ohashi, Takafumi Hara, Teruhisa Takagishi, Koji Hase, Toshiyuki Fukada

School of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

Original language	English
Pages (from-to)	2404-2415
Number of pages	12
Journal	Digestive Diseases and Sciences
Volume	64
Issue number	9
DOIs	https://doi.org/10.1007/s10620-019-05561-2
Publication status	Published - 2019 Sept 15

Keywords

Cancer
Inflammatory bowel disease
Intestinal epithelial cells
Zinc
Zinc transporter

ASJC Scopus subject areas

Physiology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10620-019-05561-2

Cite this

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abstract = "Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.",

keywords = "Cancer, Inflammatory bowel disease, Intestinal epithelial cells, Zinc, Zinc transporter",

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AU - Takagishi, Teruhisa

AU - Hase, Koji

AU - Fukada, Toshiyuki

N1 - Funding Information: Acknowledgments Some studies described herein were supported by grants from the Japan Society for the Promotion of Science (17K09373 to WO and 17H04011 to TF) and Vehicle Racing Commemorative Foundation (TF). Publisher Copyright: © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

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N2 - Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

AB - Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

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KW - Inflammatory bowel disease

KW - Intestinal epithelial cells

KW - Zinc

KW - Zinc transporter

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Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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