Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche

Fumio Arai, Toshio Suda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

174 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) are responsible for blood cell production throughout an individual's lifetime. Interaction of HSCs with their specific microenvironments, known as stem cell niches, is critical for maintaining stem cell properties, including self-renewal capacity and the ability to differentiate into multiple lineages. During postnatal life, the bone marrow (BM) supports both self-renewal and differentiation of HSCs in specialized microenvironmental niches. In the adult BM, HSCs are located in the trabecular endosteum (osteoblastic niche) or sinusoidal perivascular (vascular niche) areas. Here we show that osteoblastic cells (OBs) are a critical component for sustaining slow-cycling or quiescent HSCs. Interaction of HSCs with OBs through signaling and cell adhesion molecules maintains the balance in HSCs between cell division/proliferation and quiescence. In particular, the quiescent state is thought to be an essential mechanism to protect HSCs from stress and to sustain long-term hematopoiesis.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages41-53
Number of pages13
Volume1106
DOIs
Publication statusPublished - 2007 Jun

Publication series

NameAnnals of the New York Academy of Sciences
Volume1106
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Hematopoietic Stem Cells
Stem cells
Maintenance
Bone Marrow
Stem Cell Niche
Bone
Cells
Hematopoiesis
Cell Adhesion Molecules
Cell Division
Blood Vessels
Blood Cells
Stem Cells
Cell Proliferation
Blood

Keywords

  • Angiopoietin-1
  • Ataxia telangiectasia mutated (ATM)
  • Hematopoietic stem cell
  • N-cadherin
  • Osteoblastic cells
  • p38MAPK
  • Quiescence
  • Reactive oxygen species (ROS)
  • Tie2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Arai, F., & Suda, T. (2007). Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. In Annals of the New York Academy of Sciences (Vol. 1106, pp. 41-53). (Annals of the New York Academy of Sciences; Vol. 1106). https://doi.org/10.1196/annals.1392.005

Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. / Arai, Fumio; Suda, Toshio.

Annals of the New York Academy of Sciences. Vol. 1106 2007. p. 41-53 (Annals of the New York Academy of Sciences; Vol. 1106).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arai, F & Suda, T 2007, Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. in Annals of the New York Academy of Sciences. vol. 1106, Annals of the New York Academy of Sciences, vol. 1106, pp. 41-53. https://doi.org/10.1196/annals.1392.005
Arai F, Suda T. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. In Annals of the New York Academy of Sciences. Vol. 1106. 2007. p. 41-53. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1392.005
Arai, Fumio ; Suda, Toshio. / Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Annals of the New York Academy of Sciences. Vol. 1106 2007. pp. 41-53 (Annals of the New York Academy of Sciences).
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