Malignant brain tumor with rhabdoid features in an adult

Case report

Jun Mutou, Yuichi Hirose, Eiji Ikeda, Kazunari Yoshida, Yoichi Nakazato, Takeshi Kawase

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rhabdoid tumor (RT) of the central nervous system is an uncommon and aggressive neoplasm that usually affects pediatric patients. Currently, these tumors are classified as malignant RT or atypical teratoid/RT. Another entity of intraparenchymal brain tumor with a rhabdoid component is the extremely rare rhabdoid glioblastoma. A 23-year-old woman presented with a malignant RT in the right thalamus. The tumor was adjacent to the right lateral ventricle and was partially resected. Histological examination revealed prominent proliferation of rhabdoid cells, which is consistent with a diagnosis of malignant RT; the typical features of glioblastoma were not observed. The tumor cells stained positively for integrase interactor-1 and glial fibrillary acidic protein. Therefore, the tumor may have originated from glial components. Genetic analysis using comparative genomic hybridization showed a deoxyribonucleic acid copy-number gain on chromosome 7 but not on chromosome 22. The tumor did not respond to chemotherapy or radiotherapy, and the patient survived for only 4 months after surgery. The present case of malignant RTs shows certain similarities with those of rhabdoid glioblastoma. Further accumulation and analysis of data, including data from genetic analyses, may lead to the identification of a new type of malignant RT.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalNeurologia Medico-Chirurgica
Volume51
Issue number6
DOIs
Publication statusPublished - 2011

Fingerprint

Rhabdoid Tumor
Brain Neoplasms
Glioblastoma
Neoplasms
Nervous System Neoplasms
Integrases
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 7
Comparative Genomic Hybridization
Lateral Ventricles
Glial Fibrillary Acidic Protein
Thalamus
Neuroglia
Heart Ventricles
Radiotherapy
Central Nervous System
Cell Proliferation
Pediatrics
Drug Therapy
DNA

Keywords

  • Adult
  • Atypical teratoid/rhabdoid tumor
  • Comparative genomic hybridization
  • Intracerebral malignant rhabdoid tumor
  • Rhabdoid glioblastoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Malignant brain tumor with rhabdoid features in an adult : Case report. / Mutou, Jun; Hirose, Yuichi; Ikeda, Eiji; Yoshida, Kazunari; Nakazato, Yoichi; Kawase, Takeshi.

In: Neurologia Medico-Chirurgica, Vol. 51, No. 6, 2011, p. 449-454.

Research output: Contribution to journalArticle

Mutou, J, Hirose, Y, Ikeda, E, Yoshida, K, Nakazato, Y & Kawase, T 2011, 'Malignant brain tumor with rhabdoid features in an adult: Case report', Neurologia Medico-Chirurgica, vol. 51, no. 6, pp. 449-454. https://doi.org/10.2176/nmc.51.449
Mutou, Jun ; Hirose, Yuichi ; Ikeda, Eiji ; Yoshida, Kazunari ; Nakazato, Yoichi ; Kawase, Takeshi. / Malignant brain tumor with rhabdoid features in an adult : Case report. In: Neurologia Medico-Chirurgica. 2011 ; Vol. 51, No. 6. pp. 449-454.
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