Malignant germ cell tumor of the mediastinum: A multimodality therapeutic approach

Hisao Asamura, Ryosuke Tsuchiya, Tomoyuki Goya, Haruhiko Kondo, Tsuguo Naruke, Nagahiro Saijo, Kehchi Suemasu

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Abstract

Twenty-five patients with a malignant germ cell tumor of the mediastinum were treated at the National Cancer Center Hospital, Tokyo. Three patients had pure seminomas while 22 had a nonseminomatous histology. The treatment modalities consisted of surgery alone in 7 patients, surgery with chemotherapy and/or radiation in 14, and chemotherapy and/or radiation without surgery in 4. Cisplatin-based chemotherapy was administered in nine patients, one of whom successfully underwent high-dose chemotherapy with autologous bone marrow transplantation after resection of the tumor. A complete response was achieved in only five patients. The overall survival rate at 5 years was 33.5% and the median survival time was 51 weeks. Eight patients (32%), all of whom underwent surgery either with or without chemotherapy and/or radiation, were free of disease with a mean follow-up period of 439 weeks (72-1,120 weeks). The median survival times for 14 patients undergoing combined modality treatment, 7 patients undergoing surgery alone, and 4 patients undergoing chemotherapy and/or radiation were 83, 16, and 18 weeks, respectively.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalSurgery today
Volume24
Issue number2
DOIs
Publication statusPublished - 1994 Feb 1

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Keywords

  • germ cell tumor
  • mediastinal tumor

ASJC Scopus subject areas

  • Surgery

Cite this

Asamura, H., Tsuchiya, R., Goya, T., Kondo, H., Naruke, T., Saijo, N., & Suemasu, K. (1994). Malignant germ cell tumor of the mediastinum: A multimodality therapeutic approach. Surgery today, 24(2), 137-141. https://doi.org/10.1007/BF02473395